Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.59 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.51 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.47 |
| ▸ | BMP4 | P12644 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21160911 | 0.89 | CYP11B1 (0.51) | TGFBR1PIK3CANUDT1CYP11B1CYP1A2 | |
| SCHEMBL28018834 | 0.86 | PIK3CA (0.63) | TGFBR1PIK3CANUDT1CYP11B1DYRK1A | |
| SCHEMBL35327 | 0.83 | TGFBR1 (0.60) | TGFBR1PIK3CAMAPK14GRM4DYRK1A | |
| SCHEMBL30439957 | 0.83 | TGFBR1 (0.60) | TGFBR1PIK3CAMAPK14GRM4DYRK1A | |
| SCHEMBL13907276 | 0.82 | CYP11B1 (0.66) | NUDT1CYP11B1DYRK1ACYP1A2CYP2A6 | |
| SCHEMBL11007547 | 0.81 | CYP1A2 (0.49) | TGFBR1PIK3CAMAPK14GRM4NFATC1 | |
| SCHEMBL25066730 | 0.81 | TGFBR1 (0.59) | TGFBR1PIK3CACYP11B1MAPK14GRM4 | |
| SCHEMBL18292299 | 0.81 | TGFBR1 (0.56) | TGFBR1PIK3CANUDT1CYP11B1MAPK14 | |
| SCHEMBL30921505 | 0.81 | TGFBR1 (0.80) | TGFBR1PIK3CANUDT1CYP11B1MAPK14 | |
| SCHEMBL28018839 | 0.80 | NUDT1 (0.58) | PIK3CANUDT1CYP11B1DYRK1ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837832-B | GDF-8 inhibitors | 里格尔药品股份有限公司 | 2019-04-26 | — | — | CN | claimed |
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | claimed |
| CN-112961102-B | Metal complex and electron transport material using the same | 大电株式会社 | 2024-03-12 | — | — | CN | disclosed |
| CN-109689665-B | Metal complex and electron transport material using the same | 大电株式会社 | 2021-10-01 | — | — | CN | disclosed |
| CN-112961102-A | Metal complex and electron transport material using the same | 大电株式会社 | 2021-06-15 | — | — | CN | disclosed |
| CN-104837832-B | GDF-8 inhibitors | 里格尔药品股份有限公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-106536507-A | 2,3-disubstituted pyridine compounds as TGF-beta inhibitors and methods of use | 里格尔药品股份有限公司 | 2017-03-22 | — | — | CN | disclosed |
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | disclosed |