SCHEMBL28020074

SCHEMBL28020074

CC(C)COc1ccccc1C(=O)OC(C)C

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.53
TSHR P16473 1/20 0.53
NPC1 O15118 1/20 0.51
ABCB1 P08183 4/20 0.49
HTT P42858 1/20 0.48
KDM4E B2RXH2 2/20 0.47
LMNA P02545 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
ADRB2 P07550 1/20 0.43
ADRB1 P08588 1/20 0.43
ADRB3 P13945 1/20 0.43
PTGS2 P35354 1/20 0.43
PDK2 Q15119 1/20 0.43
IRAK4 Q9NWZ3 1/20 0.42
PDCD1 Q15116 1/20 0.42
CD274 Q9NZQ7 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28020498 0.85 ALDH1A1 (0.74) ALDH1A1TSHRNPC1ABCB1HTT
SCHEMBL385218 0.85 ALDH1A1 (0.54) ALDH1A1TSHRHTTLMNASMN1; SMN2
SCHEMBL10324240 0.85 HCRTR1 (0.55) ALDH1A1NPC1HTTKDM4ELMNA
SCHEMBL3339926 0.85 ABCB1 (0.64) ALDH1A1TSHRABCB1HTTKDM4E
SCHEMBL25063217 0.84 ALDH1A1 (0.53) ALDH1A1TSHRABCB1HTTKDM4E
SCHEMBL24074185 0.84 ALDH1A1 (0.53) ALDH1A1TSHRABCB1HTTKDM4E
SCHEMBL4337394 0.84 ALDH1A1 (0.53) ALDH1A1TSHRABCB1HTTKDM4E
SCHEMBL7926507 0.83 ALDH1A1 (0.51) ALDH1A1TSHRABCB1HTTKDM4E
SCHEMBL28020536 0.83 TSHR (0.61) ALDH1A1TSHRABCB1HTTKDM4E
SCHEMBL28020528 0.83 ADRB2 (0.57) ALDH1A1NPC1ABCB1HTTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104829756-B A kind of solid catalyst component for olefine polymerization and its preparation method and application 中国科学院化学研究所 2018-05-15 CN disclosed
CN-104829756-A Solid catalyst component for olefin polymerization, and preparation method and application thereof CHINESE ACAD INST CHEMISTRY 2015-08-12 CN disclosed