SCHEMBL28021131

SCHEMBL28021131

Brc1cccc(CN2CCCN(Cc3cccc(Br)n3)C2)n1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 0.49
CXCR4 P61073 2/20 0.46
KDM4E B2RXH2 2/20 0.41
MPO P05164 1/20 0.41
DRD2 P14416 2/20 0.39
DRD3 P35462 2/20 0.39
ACHE P22303 1/20 0.38
PARP1 P09874 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
KDM1A O60341 1/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL839038 0.88 FAAH (0.53) FAAHCXCR4KDM4EDRD2DRD3
SCHEMBL13940602 0.84 FAAH (0.51) FAAHCXCR4KDM4EDRD2DRD3
SCHEMBL3671476 0.79 FAAH (0.43) FAAHPARP1TDP1CYP2D6
SCHEMBL839624 0.79 FAAH (0.46) FAAHCXCR4KDM4EDRD2DRD3
SCHEMBL31372331 0.78 CXCR4 (0.77) FAAHCXCR4KDM4ESMN1; SMN2ALDH1A1
SCHEMBL29462386 0.78 FAAH (0.54) FAAHCXCR4KDM4EDRD2DRD3
SCHEMBL5255062 0.78 FAAH (0.54) FAAHCXCR4KDM4EDRD2DRD3
SCHEMBL838783 0.78 FAAH (0.51) FAAHCXCR4KDM4EDRD2DRD3
SCHEMBL5253618 0.78 FAAH (0.54) FAAHCXCR4KDM4EDRD2DRD3
SCHEMBL465778 0.78 CXCR4 (0.77) FAAHCXCR4KDM4ESMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104744519-B Ring expansion N-heterocyclic carbine palladium compound containing picolyl 河南工业大学 2017-10-24 CN disclosed
CN-104744519-A Ring enlargement azoheterocyclic carbene-palladium compound containing picolyl UNIV HENAN TECHNOLOGY 2015-07-01 CN disclosed