Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3675615 | 0.97 | HRH3 (0.46) | FAAHHRH3SLC6A3SIGMAR1L3MBTL1 | |
| SCHEMBL839038 | 0.77 | FAAH (0.53) | FAAHHRH3TDP1CYP2D6 | |
| SCHEMBL19461950 | 0.76 | LTA4H (0.48) | HRH3SIGMAR1L3MBTL1TDP1 | |
| SCHEMBL12666994 | 0.76 | CXCR4 (0.54) | HRH3SLC6A3SIGMAR1L3MBTL1TDP1 | |
| SCHEMBL13940602 | 0.74 | FAAH (0.51) | FAAHTDP1PARP1 | |
| SCHEMBL6434949 | 0.74 | KDM1A (0.41) | FAAHPARP1 | |
| SCHEMBL18971805 | 0.72 | FAAH (0.38) | FAAHTDP1PARP1 | |
| SCHEMBL30786223 | 0.72 | SLC6A3 (0.42) | HRH3SLC6A3SIGMAR1L3MBTL1TDP1 | |
| SCHEMBL1022831 | 0.71 | KCNH2 (0.40) | FAAHTDP1PARP1 | |
| SCHEMBL5253618 | 0.71 | FAAH (0.54) | FAAHTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |