Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 13/20 | 0.43 |
| ▸ | AURKA | O14965 | 10/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28021678 | 0.86 | ATM (0.45) | ATMAURKBAURKAALDH1A1CA12 | |
| SCHEMBL28021591 | 0.85 | AURKB (0.51) | ATMAURKBAURKAALDH1A1MEN1 | |
| SCHEMBL2201749 | 0.82 | AURKB (0.64) | AURKBAURKASRCGSK3BABL1 | |
| SCHEMBL28021603 | 0.81 | ALDH1A1 (0.42) | ATMAURKBAURKAALDH1A1CA12 | |
| SCHEMBL28021607 | 0.77 | SLC2A1 (0.44) | ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL28022078 | 0.76 | PKM (0.44) | AURKBAURKAALDH1A1CA1CA2 | |
| SCHEMBL28565368 | 0.76 | AURKB (0.44) | AURKBAURKAALDH1A1CA12CA1 | |
| SCHEMBL28022116 | 0.76 | ADORA1 (0.47) | AURKBAURKAALDH1A1MEN1MAPT | |
| SCHEMBL28570313 | 0.76 | KMT2A (0.37) | AURKAALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL27577294 | 0.75 | AURKB (0.40) | AURKBAURKAMEN1KMT2ASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104797267-A | Method of treating tyrosine kinase inhibitor-resistant malignancies in patients with genetic polymorphism or AHI1 dysregulation or mutation using dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof | DEL MAR PHARMACEUTICALS | 2015-07-22 | — | — | CN | disclosed |