Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28021626 | 0.86 | ATM (0.46) | ATMKMT2AALDH1A1MEN1POLB | |
| SCHEMBL28021591 | 0.84 | AURKB (0.51) | ATMKMT2AALDH1A1MEN1GAA | |
| SCHEMBL28021603 | 0.82 | ALDH1A1 (0.42) | ATMKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL28549342 | 0.76 | ACHE (0.48) | KMT2AALDH1A1MEN1POLBKDM4E | |
| SCHEMBL28021607 | 0.76 | SLC2A1 (0.44) | KMT2AALDH1A1MEN1GAAKDM4E | |
| SCHEMBL28022078 | 0.76 | PKM (0.44) | KMT2AALDH1A1MEN1GAAPOLB | |
| SCHEMBL28565368 | 0.75 | AURKB (0.44) | KMT2AALDH1A1MEN1KDM4EMAPT | |
| SCHEMBL28022116 | 0.75 | ADORA1 (0.47) | KMT2AALDH1A1MEN1GAAPOLB | |
| SCHEMBL28557357 | 0.73 | AURKB (0.49) | KMT2AALDH1A1MEN1POLBKDM4E | |
| SCHEMBL28022048 | 0.73 | AURKA (0.46) | ALDH1A1POLBKDM4EMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104797267-A | Method of treating tyrosine kinase inhibitor-resistant malignancies in patients with genetic polymorphism or AHI1 dysregulation or mutation using dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof | DEL MAR PHARMACEUTICALS | 2015-07-22 | — | — | CN | disclosed |