Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 3/20 | 0.51 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5579673 | 0.79 | PTGES (0.64) | HDAC6SRD5A2MEN1KMT2ANPC1 | |
| SCHEMBL5349165 | 0.76 | BRAF (0.49) | BRAFRAF1 | |
| SCHEMBL8305123 | 0.75 | HTR3A (0.54) | SRD5A2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3771751 | 0.74 | RAB9A (0.74) | HDAC6MEN1KMT2ANPC1RAB9A | |
| SCHEMBL22382419 | 0.74 | EHMT2 (0.53) | HDAC6NPC1RAB9A | |
| SCHEMBL19058673 | 0.74 | HDAC6 (1.00) | HDAC6 | |
| SCHEMBL4464733 | 0.73 | SRD5A2 (0.81) | SRD5A2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4470968 | 0.73 | SRD5A2 (1.00) | SRD5A2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6320502 | 0.72 | HDAC6 (0.53) | HDAC6NPC1RAB9AMAPT | |
| SCHEMBL457343 | 0.72 | TP53 (0.52) | HDAC6MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104876878-B | - 2 alkyl substituted urea benzimidazoles compound of 5- aryl phenols and its application | 中国科学院广州生物医药与健康研究院 | 2018-04-27 | — | — | CN | disclosed |
| CN-104876878-A | 5-aryl phenol-2 alkyl substituted urea benzimidazole compound and applications thereof | GUANGZHOU INST BIOMED & HEALTH | 2015-09-02 | — | — | CN | disclosed |