Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.41 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.41 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KDM5C | P41229 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL18329309 | 1.00 | LMNA (0.53) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Mercaptopropionic Acid SCHEMBL28297550 | 0.85 | ACE (0.46) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Butyric Acid SCHEMBL27447655 | 0.85 | FFAR3 (0.62) | MAPK1TDP1OR51E2SLC22A6TSHR | |
| Butyric Acid SCHEMBL28543441 | 0.85 | FFAR3 (0.62) | MAPK1TDP1OR51E2SLC22A6TSHR | |
| Glycolic Acid SCHEMBL6040104 | 0.82 | MAPK1 (0.47) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Malonic Acid SCHEMBL9318328 | 0.82 | LDHA (0.53) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Furan SCHEMBL7296766 | 0.81 | — | — | |
| Furan SCHEMBL5278070 | 0.81 | MAPK1 (0.61) | MAPK1TDP1 | |
| Furan SCHEMBL27656052 | 0.81 | MAPK1 (0.61) | MAPK1TDP1 | |
| Succinic Acid SCHEMBL4739951 | 0.80 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107496380-B | A kind of succinic acid furan Luo Qutan sustained-release micro-spheres and preparation method thereof | 正大制药（青岛）有限公司 | 2019-10-01 | — | — | CN | claimed |
| CN-107375225-B | Level release formulation of a kind of succinic acid furan Luo Qu and preparation method thereof | 青岛正大海尔制药有限公司 | 2019-10-01 | — | — | CN | claimed |
| CN-105412039-A | Frovatriptan succinate controlled-release tablet and preparation method thereof | QINGDAO CHIA TAI HAIER PHARMACEUTICAL CO LTD | 2016-03-23 | — | — | CN | claimed |
| CN-105412023-A | Frovatriptan succinate controlled-release granule and preparation method thereof | QINGDAO CHIA TAI HAIER PHARMACEUTICAL CO LTD | 2016-03-23 | — | — | CN | claimed |
| CN-104800184-A | Slow-release tablet comprising succinate frovatriptan | QINGDAO CHIA TAI HAIER PHARMACEUTICAL CO LTD | 2015-07-29 | — | — | CN | claimed |
| CN-104758268-A | Frovatriptan succinate tablet and preparation method thereof | QINGDAO CHIA TAI HAIER PHARMACEUTICAL CO LTD | 2015-07-08 | — | — | CN | claimed |
| CN-107496380-B | A kind of succinic acid furan Luo Qutan sustained-release micro-spheres and preparation method thereof | 正大制药（青岛）有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-107496380-B | A kind of succinic acid furan Luo Qutan sustained-release micro-spheres and preparation method thereof | 正大制药（青岛）有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-107496380-B | A kind of succinic acid furan Luo Qutan sustained-release micro-spheres and preparation method thereof | 正大制药（青岛）有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-107375225-B | Level release formulation of a kind of succinic acid furan Luo Qu and preparation method thereof | 青岛正大海尔制药有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-107375225-B | Level release formulation of a kind of succinic acid furan Luo Qu and preparation method thereof | 青岛正大海尔制药有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-107375225-B | Level release formulation of a kind of succinic acid furan Luo Qu and preparation method thereof | 青岛正大海尔制药有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-105412039-A | Frovatriptan succinate controlled-release tablet and preparation method thereof | QINGDAO CHIA TAI HAIER PHARMACEUTICAL CO LTD | 2016-03-23 | — | — | CN | disclosed |
| CN-105412023-A | Frovatriptan succinate controlled-release granule and preparation method thereof | QINGDAO CHIA TAI HAIER PHARMACEUTICAL CO LTD | 2016-03-23 | — | — | CN | disclosed |
| CN-104800184-A | Slow-release tablet comprising succinate frovatriptan | QINGDAO CHIA TAI HAIER PHARMACEUTICAL CO LTD | 2015-07-29 | — | — | CN | disclosed |
| CN-104758268-A | Frovatriptan succinate tablet and preparation method thereof | QINGDAO CHIA TAI HAIER PHARMACEUTICAL CO LTD | 2015-07-08 | — | — | CN | disclosed |