Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27933965 | 0.80 | ALDH1A1 (0.38) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL28022831 | 0.78 | MEN1 (0.39) | BTKMEN1KMT2AALDH1A1ADRA2A | |
| SCHEMBL28022338 | 0.78 | MEN1 (0.39) | BTKMEN1KMT2AALDH1A1ADRA2A | |
| SCHEMBL28288979 | 0.74 | HRH3 (0.36) | HSD17B10HRH3 | |
| SCHEMBL1297246 | 0.72 | BTK (0.45) | HSD17B10BTKMEN1KMT2AHRH3 | |
| SCHEMBL17336143 | 0.69 | CHRM2 (0.48) | GPR119HSD17B10MEN1KMT2AALDH1A1 | |
| SCHEMBL15369037 | 0.68 | BTK (0.41) | GPR119BTKALDH1A1HRH3 | |
| SCHEMBL23004339 | 0.68 | BTK (0.47) | HSD17B10BTKMEN1KMT2A | |
| SCHEMBL1296980 | 0.68 | BTK (0.44) | BTKALDH1A1SMN1; SMN2 | |
| SCHEMBL15023147 | 0.68 | BTK (0.47) | HSD17B10BTKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104703980-A | Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives | ACTELION PHARMACEUTICALS LTD | 2015-06-10 | — | — | CN | disclosed |