Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HMGCR | P04035 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL11405164 | 0.89 | FFAR3 (0.50) | TSHRALDH1A1HMGCRCHRM1TBXA2R | |
| Hydrogen Peroxide SCHEMBL27514068 | 0.88 | — | — | |
| Acetic Acid SCHEMBL27557379 | 0.86 | FFAR3 (0.47) | TSHRALDH1A1HMGCRCHRM1TBXA2R | |
| Pivalate SCHEMBL27623020 | 0.86 | TSHR (0.44) | TSHRALDH1A1HMGCRCHRM1TBXA2R | |
| SCHEMBL5827 | 0.83 | — | — | |
| Malonic Acid SCHEMBL28848011 | 0.83 | LDHA (0.56) | TSHRALDH1A1HMGCRCHRM1TBXA2R | |
| Bicarbonate SCHEMBL10646474 | 0.81 | TSHR (0.39) | TSHRALDH1A1HMGCRCHRM1TBXA2R | |
| Bicarbonate SCHEMBL4899717 | 0.81 | ALDH1A1 (0.47) | TSHRALDH1A1HMGCRCHRM1TBXA2R | |
| Bicarbonate SCHEMBL5187608 | 0.81 | TSHR (0.39) | TSHRALDH1A1HMGCRCHRM1TBXA2R | |
| SCHEMBL31518860 | 0.81 | TSHR (0.33) | TSHRALDH1A1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110249470-A | For alkali metal-sulphur system secondary cell electrolyte and alkali metal-sulphur system secondary cell | 学校法人关西大学 | 2019-09-17 | — | — | CN | disclosed |
| CN-106133986-B | Electrolyte and electrochemical device | 大金工业株式会社 | 2019-07-09 | — | — | CN | disclosed |
| CN-106415910-B | Nonaqueous electrolyte solution and nonaqueous electrolyte secondary battery using same | 三菱化学株式会社 | 2019-05-03 | — | — | CN | disclosed |
| CN-109301162-A | NONAQUEOUS ELECTROLYTE SOLUTION AND NONAQUEOUS ELECTROLYTE BATTERY USING SAME | 三菱化学株式会社 | 2019-02-01 | — | — | CN | disclosed |
| CN-105074994-B | Nonaqueous electrolyte solution and nonaqueous electrolyte battery using same | 三菱化学株式会社 | 2018-10-19 | — | — | CN | disclosed |
| CN-107078352-A | Nonaqueous electrolyte solution and nonaqueous electrolyte secondary battery using same | 三菱化学株式会社 | 2017-08-18 | — | — | CN | disclosed |
| CN-106415910-A | Nonaqueous electrolyte solution and nonaqueous electrolyte secondary battery using same | 三菱化学株式会社 | 2017-02-15 | — | — | CN | disclosed |
| CN-106133986-A | Electrolyte and electrochemical device | 大金工业株式会社 | 2016-11-16 | — | — | CN | disclosed |
| CN-106104898-A | Electrolyte, electrochemical device, lithium rechargeable battery and assembly | 大金工业株式会社 | 2016-11-09 | — | — | CN | disclosed |
| CN-105555381-A | Method for treating mixed solution | SANWA YUKA KOGYO CO LTD | 2016-05-04 | — | — | CN | disclosed |
| CN-102484284-B | Nonaqueous electrolyte battery and nonaqueous electrolyte solution | MITSUBISHI CHEMICAL CORP. (JP) | 2016-04-20 | — | — | CN | disclosed |
| CN-105074994-A | Nonaqueous electrolyte solution and nonaqueous electrolyte battery using same | MITSUBISHI CHEM CORP | 2015-11-18 | — | — | CN | disclosed |
| CN-104704671-A | Electrolyte solution, electrochemical device, lithium battery, and module | DAIKIN IND LTD | 2015-06-10 | — | — | CN | disclosed |