Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HMGCR | P04035 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL42569 | 0.84 | — | — | |
| SCHEMBL12478173 | 0.84 | — | — | |
| Bicarbonate SCHEMBL29012528 | 0.83 | HMGCR (0.50) | ALDH1A1TSHRHMGCRCHRM1TBXA2R | |
| Bicarbonate SCHEMBL28022644 | 0.81 | TSHR (0.41) | ALDH1A1TSHRHMGCRCHRM1TBXA2R | |
| SCHEMBL28445600 | 0.81 | — | — | |
| Ammonia Solution, Strong SCHEMBL11671050 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL28329186 | 0.81 | — | — | |
| Water SCHEMBL9815441 | 0.81 | — | — | |
| SCHEMBL28664930 | 0.81 | — | — | |
| Acrylic Acid SCHEMBL10936959 | 0.80 | LMNA (0.53) | ALDH1A1TSHRHMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4082729-A | PROCESS FOR THE PREPARATION OF OXYMETHYLENE POLYMERS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-04-04 | — | — | US | claimed |
| EP-3442354-B1 | FORMULATION AND PRODUCTION OF SPINACH EXTRACT WITH BETA ECDYSON | DR GOETZ GMBH (DE) | 2026-05-20 | — | — | EP | disclosed |
| EP-3454825-B1 | AROMA PREPARATIONS CONTAINING MENTHOL | SYMRISE AG (DE) | 2026-05-06 | — | — | EP | disclosed |
| EP-3463588-B1 | USE OF GINGER ROOT CO2 EXTRACT | SYMRISE AG (DE) | 2025-09-17 | — | — | EP | disclosed |
| US-12369600-B2 | Cooling composition | SYMRISE AG (DE) | 2025-07-29 | — | — | US | disclosed |
| US-20250163006-A1 | New Coolants, and Preparations Containing Same | SYMRISE AG (DE) | 2025-05-22 | — | — | US | disclosed |
| CN-119486725-A | (2E) Mixtures and uses of (E) -3- (1, 3-benzodioxol-5-yl) -N-phenyl-N- (tetrahydro-3-furanyl) -2-propenamide | 西姆莱斯有限公司 | 2025-02-18 | — | — | CN | disclosed |
| WO-2025026525-A1 | HETEROCYCLIC COMPOUNDS AS PHYSIOLOGICAL COOLANTS | SYMRISE AG (DE) | 2025-02-06 | — | — | WO | disclosed |
| CN-115322833-B | Perfume mixture | 西姆莱斯股份公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-119255781-A | Antimicrobial mixtures | 西姆莱斯股份公司 | 2025-01-03 | — | — | CN | disclosed |
| US-20160200866-A1 | CROSS-LINKING OF POLYETHER CARBONATE POLYOLS CONTAINING DOUBLE-BONDS, BY ADDING MERCAPTO-COMPOUNDS | COVESTRO DEUTSCHLAND AG (DE) | 2016-07-14 | — | — | US | disclosed |
| US-20160200865-A1 | RADICAL CROSSLINKING OF POLYETHER CARBONATE POLYOLS THAT HAVE ELECTRON-POOR AND ELECTRON-RICH DOUBLE BONDS | COVESTRO DEUTSCHLAND AG (DE) | 2016-07-14 | — | — | US | disclosed |
| US-20160194444-A1 | HIGHER FUNCTIONAL POLYETHER CARBONATE POLYOLS OBTAINED USING BRANCHING MOLECULES | COVESTRO DEUTSCHLAND AG (DE) | 2016-07-07 | — | — | US | disclosed |
| US-20160185903-A1 | LOW VISCOSITY POLYETHER CARBONATE POLYOLS HAVING SIDE CHAINS | COVESTRO DEUTSCHLAND AG (DE) | 2016-06-30 | — | — | US | disclosed |
| US-20160130407-A1 | POLYETHERCARBONATE-POLYOXYMETHYLENE BLOCK COPOLYMERS | COVESTRO DEUTSCHLAND AG (DE) | 2016-05-12 | — | — | US | disclosed |
| US-9273183-B2 | Polyether carbonate polyol production method | COVESTRO DEUTSCHLAND AG (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20150368396-A1 | FUNCTIONALIZED POLYOXYMETHYLENE BLOCK COPOLYMERS | COVESTRO DEUTSCHLAND AG (DE) | 2015-12-24 | — | — | US | disclosed |
| US-20150225503-A1 | POLYETHER CARBONATE POLYOL PRODUCTION METHOD | COVESTRO DEUTSCHLAND AG (DE) | 2015-08-13 | — | — | US | disclosed |
| US-20080097077-A1 | Method For Producing Polyoxymethylenes | BASF AKTIENGESELLSCHAFT (DE) | 2008-04-24 | — | — | US | disclosed |
| US-4082729-A | PROCESS FOR THE PREPARATION OF OXYMETHYLENE POLYMERS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12369600-B2 | Cooling composition | TAS2R5, TAS2R20, TAS2R60 | ALDH1A1 976/4885TSHR 4499/4885HMGCR 442/4885 |
| US-20250163006-A1 | New Coolants, and Preparations Containing Same | TTR, TAS2R5, TAS2R50 | ALDH1A1 811/4885TSHR 2090/4885HMGCR 2036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.