SCHEMBL28022707

SCHEMBL28022707

O=C(CCc1ccccc1)c1ccccc1-c1cccc(F)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.52
HTT P42858 1/20 0.49
FAAH O00519 1/20 0.47
LPAR1 Q92633 1/20 0.47
FFAR1 O14842 3/20 0.46
TUBB4A P04350 1/20 0.46
TUBB P07437 1/20 0.46
TUBA3C P0DPH7 1/20 0.46
TUBA1B P68363 1/20 0.46
TUBA4A P68366 1/20 0.46
TUBB4B P68371 1/20 0.46
TUBB3 Q13509 1/20 0.46
TUBB2A Q13885 1/20 0.46
TUBB8 Q3ZCM7 1/20 0.46
TUBA3E Q6PEY2 1/20 0.46
TUBA1A Q71U36 1/20 0.46
TUBA1C Q9BQE3 1/20 0.46
TUBB6 Q9BUF5 1/20 0.46
TUBB2B Q9BVA1 1/20 0.46
TUBB1 Q9H4B7 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18896859 0.89 TUBB4A (0.42) HCAR2HTTFAAHLPAR1FFAR1
SCHEMBL28023427 0.85 GPR52 (0.56) FFAR1GPR52RAB9AMAPTCYP19A1
SCHEMBL7499861 0.84 HTT (0.50) HCAR2HTTFAAHFFAR1TUBB4A
SCHEMBL28022702 0.81 HCAR2 (0.56) HCAR2HTTFAAHLPAR1FFAR1
SCHEMBL27966450 0.80 TUBB4A (0.50) HTTTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL269851 0.79 HTT (0.59) HCAR2HTTLPAR1TUBB4ATUBB
SCHEMBL31397801 0.79 HTT (0.59) HCAR2HTTLPAR1TUBB4ATUBB
SCHEMBL5361790 0.77 LPAR1 (0.56) HTTLPAR1
SCHEMBL29579853 0.76 GPR52 (0.58) HTTFFAR1GPR52POLBRAB9A
SCHEMBL28128458 0.76 GPR52 (0.58) HTTFFAR1GPR52POLBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104860803-B Biphenyl ketonic compound and its preparation method and application 暨南大学 2016-11-30 CN disclosed
CN-104860803-A Biphenyl compound and preparation method and application thereof UNIV JINAN 2015-08-26 CN disclosed