Sugi Predict

Sugi Predict / Compounds / SCHEMBL280229

SCHEMBL280229

SCHEMBL280229

CCOC(=O)C(N)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MMP8 P22894 1/20 0.56
▸ PIN1 Q13526 1/20 0.51
▸ KMT2A Q03164 2/20 0.50
▸ MEN1 O00255 1/20 0.50
▸ NPC1 O15118 1/20 0.50
▸ SMN1; SMN2 Q16637 2/20 0.49
▸ TSHR P16473 2/20 0.47
▸ GAA P10253 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ CYP1A2 P05177 1/20 0.46
▸ CYP2D6 P10635 1/20 0.46
▸ PKM P14618 1/20 0.46
▸ NPSR1 Q6W5P4 1/20 0.46
▸ CA12 O43570 1/20 0.46
▸ CA1 P00915 1/20 0.46
▸ CA2 P00918 1/20 0.46
▸ CA9 Q16790 1/20 0.46
▸ SLC6A2 P23975 1/20 0.46
▸ SLC6A4 P31645 1/20 0.46
▸ SLC6A3 Q01959 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL340846 1.00 MMP8 (0.56) MMP8PIN1KMT2AMEN1NPC1
SCHEMBL8129701 1.00 MMP8 (0.56) MMP8PIN1KMT2AMEN1NPC1
Hydrochloric Acid SCHEMBL1630960 0.98 PIN1 (0.54) MMP8PIN1KMT2AMEN1NPC1
Hydrochloric Acid SCHEMBL28989563 0.98 PIN1 (0.54) MMP8PIN1KMT2AMEN1NPC1
Hydrochloric Acid SCHEMBL1851016 0.98 PIN1 (0.54) MMP8PIN1KMT2AMEN1NPC1
SCHEMBL10599023 0.90 KCNH2 (0.44) MMP8PIN1KMT2AMEN1NPC1
SCHEMBL7788579 0.87 MMP8 (0.46) MMP8PIN1KMT2AMEN1NPC1
SCHEMBL31059195 0.87 NPC1 (0.54) MMP8PIN1NPC1SMN1; SMN2TDP1
SCHEMBL9667155 0.87 MEN1 (0.50) MMP8PIN1KMT2AMEN1NPC1
SCHEMBL31556288 0.85 LMNA (0.53) MMP8KMT2ANPC1SMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 163 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144384-B1 COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARM INC (US) 2007-10-31 — — EP claimed
CN-1856477-A Isoquinoline potassium channel inhibitors MERCK & CO INC (US) 2006-11-01 — — CN claimed
US-4236026-A Separation of stereoisomeric vinylcyclopropanecarboxylic acids BAYER AKTIENGESELLSCHAFT (DE) 1980-11-25 — — US claimed
US-12622909-B2 Allosteric EGFR inhibitors and methods of use thereof DANA-FARBER CANCER INSTITUTE, INC. (US) 2026-05-12 — — US disclosed
US-20250340534-A1 ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF DANA-FARBER CANCER INSTITUTE, INC. (US) 2025-11-06 — — US disclosed
US-20250340535-A1 ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF DANA-FARBER CANCER INSTITUTE, INC. (US) 2025-11-06 — — US disclosed
US-12391671-B2 Allosteric EGFR inhibitors and methods of use thereof DANA-FARBER CANCER INSTITUTE, INC. (US) 2025-08-19 — — US disclosed
US-20250230137-A1 P300/CBP HAT INHIBITORS CONSTELLATION PHARMACEUTICALS INC (US) 2025-07-17 — — US disclosed
CN-114206342-B Allosteric EGFR inhibitors and methods of use thereof 达纳-法伯癌症研究所股份有限公司 2024-10-22 — — CN disclosed
EP-3752497-B1 P300/CBP HAT INHIBITORS CONSTELLATION PHARMACEUTICALS INC (US) 2024-07-17 — — EP disclosed
CN-117720446-A Green methionine synthesis method 新疆兴发化工有限公司 2024-03-19 — — CN disclosed
WO-1997049706-A1 SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF NOVARTIS AG (CH) 1997-12-31 — — WO disclosed
US-5691335-A CARDIOVASCULAR DISORDERS SUNTORY LIMITED (JP) 1997-11-25 — — US disclosed
CN-1163422-A Silver halide photosensitive emulsion layer with enhanced photosensitivity EASTMAN KODAK CO (US) 1997-10-29 — — CN disclosed
EP-0721944-A1 IMIDAZOLIDINE DERIVATIVE AND USE THEREOF SUNTORY LIMITED (JP) 1996-07-17 — — EP disclosed
US-5175159-A Prevention of premature labor MERCK & CO., INC. (US) 1992-12-29 — — US disclosed
US-4565843-A Lacquer solutions based on hydantoin group-containing polymers BAYER AKTIENGESELLSCHAFT (DE) 1986-01-21 — — US disclosed
US-4517353-A Process for preparation of hydantoin esters through a masked polyisocyanate-carbodiimide route BAYER AKTIENGESELLSCHAFT (DE) 1985-05-14 — — US disclosed
US-4443475-A ANTIARRHYTHMIA AGENTS, ANTIDEPRESSANTS CAVAZZA CLAUDIO (IT) 1984-04-17 — — US disclosed
US-4236026-A Separation of stereoisomeric vinylcyclopropanecarboxylic acids BAYER AKTIENGESELLSCHAFT (DE) 1980-11-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12622909-B2 Allosteric EGFR inhibitors and methods of use thereof EGFR, ERBB3, ERBB2 MMP8 2704/4885PIN1 4230/4885KMT2A 2644/4885
US-20250340535-A1 ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF EGFR, ERBB2, ERBB3 MMP8 1203/4885PIN1 1873/4885KMT2A 4116/4885
US-12391671-B2 Allosteric EGFR inhibitors and methods of use thereof EGFR, ERBB2, ERBB3 MMP8 1203/4885PIN1 1873/4885KMT2A 4116/4885
US-20250340534-A1 ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF EGFR, ERBB2, ERBB3 MMP8 1203/4885PIN1 1873/4885KMT2A 4116/4885
US-20250230137-A1 P300/CBP HAT INHIBITORS EP300, HDAC1, KAT2A MMP8 1335/4885PIN1 4561/4885KMT2A 161/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.