Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31403174 | 0.77 | EPHX2 (0.51) | EPHX2CYP19A1XDHCYP3A4MEN1 | |
| SCHEMBL3606688 | 0.76 | GAA (0.55) | EPHX2XDHMEN1NPC1RAB9A | |
| SCHEMBL11900195 | 0.73 | EPHX2 (0.44) | EPHX2XDHMEN1NPC1RAB9A | |
| SCHEMBL11901651 | 0.73 | EPHX2 (0.55) | EPHX2XDHMEN1NPC1RAB9A | |
| SCHEMBL30173623 | 0.72 | EPHX2 (0.40) | EPHX2XDHMEN1NPC1RAB9A | |
| SCHEMBL17076791 | 0.71 | GAA (0.31) | — | |
| SCHEMBL25777245 | 0.71 | EPHX2 (0.45) | EPHX2XDHCYP3A4MEN1NPC1 | |
| SCHEMBL1038150 | 0.70 | CYP19A1 (0.52) | CYP19A1CYP3A4CYP1A2METAP2 | |
| SCHEMBL5426693 | 0.69 | SLC34A1 (0.38) | EPHX2GRM4CYP46A1GCGR | |
| SCHEMBL11900219 | 0.69 | KIF11 (0.49) | EPHX2CYP19A1XDHCYP3A4CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103370306-B | Glucagon Receptor Modulators | PFIZER INC. (US) | 2015-12-02 | — | — | CN | disclosed |
| CN-104744370-A | Glucagon receptor modulators | PFIZER | 2015-07-01 | — | — | CN | disclosed |