Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GLA | P06280 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22596400 | 0.86 | ACHE (0.51) | ACHENR3C2LMNAKDM4EGLA | |
| SCHEMBL28192543 | 0.79 | ACHE (0.51) | ACHENR3C2LMNAKDM4EGLA | |
| SCHEMBL20901309 | 0.79 | KMT2A (0.47) | GAAALDH1A1KMT2APOLBHTT | |
| SCHEMBL27788647 | 0.79 | LMNA (0.38) | ACHENR3C2LMNAKDM4EGLA | |
| SCHEMBL27839938 | 0.79 | LMNA (0.42) | ACHELMNAKDM4EGLAGAA | |
| SCHEMBL27757318 | 0.78 | NPC1 (0.44) | ACHELMNAKDM4EGAAALDH1A1 | |
| SCHEMBL1513505 | 0.77 | ACHE (0.56) | ACHELMNAKDM4EGLAGAA | |
| SCHEMBL14700558 | 0.77 | ACHE (0.49) | ACHELMNAKDM4EGLAGAA | |
| SCHEMBL862851 | 0.76 | ACHE (0.65) | ACHELMNAKDM4EGLAGAA | |
| SCHEMBL2350995 | 0.75 | LMNA (0.53) | LMNAKDM4EGLAGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102731451-B | Fused ring compound | TAKEDA PHARMACEUTICAL CO.,LTD. (JP) | 2015-07-29 | — | — | CN | disclosed |