Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.38 |
| ▸ | CDK9 | P50750 | 5/20 | 0.38 |
| ▸ | EGFR | P00533 | 5/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | ABL2 | P42684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374581 | 0.88 | LMNA (0.44) | ADORA2ALMNACYP1A2CYP2D6CYP3A4 | |
| SCHEMBL374636 | 0.84 | CYP2D6 (0.51) | ADORA2ALMNACYP1A2CYP2D6CYP3A4 | |
| SCHEMBL374544 | 0.76 | TNNI3K (0.48) | ADORA2ALMNACYP1A2CYP2D6CYP3A4 | |
| SCHEMBL374166 | 0.72 | EGFR (0.61) | LMNACYP1A2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL374274 | 0.71 | TNNI3K (0.53) | ADORA2ALMNACYP1A2CYP2D6CYP3A4 | |
| SCHEMBL8798667 | 0.70 | EGFR (0.61) | LMNAEGFRCDK1CCNB1CCNA2 | |
| SCHEMBL374504 | 0.69 | EGFR (0.64) | ADORA2ALMNACYP1A2CYP2D6CYP3A4 | |
| SCHEMBL25920563 | 0.68 | PRMT6 (0.51) | CYP1A2CYP3A4FGFR3CYP2C19CDK5 | |
| SCHEMBL27344364 | 0.68 | CYP3A4 (0.45) | ADORA2ALMNACYP1A2CYP2D6CYP3A4 | |
| SCHEMBL3431925 | 0.67 | CDK1 (0.60) | LMNACYP1A2CYP2D6CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103121972-B | As the pyrimidine urea derivatives of kinase inhibitor | NOVARTIS AG (CH) | 2015-07-29 | — | — | CN | disclosed |