SCHEMBL28024019

SCHEMBL28024019

O=C(OI)c1cccnc1C(F)(F)F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 1/20 0.45
HCRTR1 O43613 3/20 0.40
HCRTR2 O43614 3/20 0.40
NAPRT Q6XQN6 2/20 0.40
DHODH Q02127 3/20 0.39
KDM4E B2RXH2 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
HTT P42858 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CYP3A4 P08684 3/20 0.37
ALDH1A1 P00352 2/20 0.37
MAPT P10636 1/20 0.37
ALOX15 P16050 1/20 0.37
TSHR P16473 1/20 0.37
BLM P54132 1/20 0.37
AGER Q15109 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
CTNNB1 P35222 1/20 0.36
WNT3A P56704 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL844529 0.83 KDM4E (0.51) HDAC6HCRTR1HCRTR2KDM4ETDP1
SCHEMBL27853426 0.83 HDAC6 (0.45) HDAC6HCRTR1HCRTR2NAPRTDHODH
SCHEMBL28776329 0.81 HDAC6 (0.43) HDAC6HCRTR1HCRTR2NAPRTDHODH
SCHEMBL27764496 0.80 HDAC6 (0.50) HDAC6HCRTR1HCRTR2NAPRTDHODH
SCHEMBL3662007 0.80 KDM4E (0.55) HDAC6KDM4EHTTHSD17B10ALDH1A1
SCHEMBL30785815 0.80 KDM4E (0.55) HDAC6KDM4EHTTHSD17B10ALDH1A1
SCHEMBL29488337 0.79 NAPRT (0.58) HDAC6HCRTR1HCRTR2NAPRTDHODH
SCHEMBL413572 0.79 NAPRT (0.58) HDAC6HCRTR1HCRTR2NAPRTDHODH
SCHEMBL30477668 0.77 HDAC6 (0.48) HDAC6HCRTR1HCRTR2NAPRTDHODH
SCHEMBL628397 0.77 PARP1 (0.51) HDAC6HCRTR1HCRTR2NAPRTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104718206-A Azaindole carboxylic acid amides and azaindole thiocarboxylic acid amides for use as insecticides and acaricides BAYER CROPSCIENCE AG 2015-06-17 CN disclosed