Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | AGER | Q15109 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | DHODH | Q02127 | 6/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29488337 | 1.00 | NAPRT (0.58) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL27764496 | 0.86 | HDAC6 (0.50) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL3934370 | 0.85 | NAPRT (0.55) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL8686505 | 0.84 | LMNA (0.46) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL30477668 | 0.83 | HDAC6 (0.48) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL2148942 | 0.83 | HDAC6 (0.48) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL18033657 | 0.83 | HDAC6 (0.48) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL628397 | 0.83 | PARP1 (0.51) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL29687007 | 0.83 | PARP1 (0.51) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 | |
| SCHEMBL29058517 | 0.83 | SMN1; SMN2 (0.53) | NAPRTKDM4ETDP1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 363 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117447446-A | Pyridine bisamide derivative, and preparation method and application thereof | 山东京博农化科技股份有限公司 | 2024-01-26 | — | — | CN | claimed |
| EP-4232028-A1 | METHODS OF MAKING NICOTINIC ACID DERIVATIVES | Vertellus Holdings LLC (US) | 2023-08-30 | — | — | EP | claimed |
| CN-116635369-A | Process for preparing nicotinic acid derivatives | 弗特鲁斯控股有限责任公司 | 2023-08-22 | — | — | CN | claimed |
| CN-111511731-B | Olefin compounds as modulators of the farnesol X receptor | 百时美施贵宝公司 | 2023-05-23 | — | — | CN | claimed |
| WO-2022087373-A1 | METHODS OF MAKING NICOTINIC ACID DERIVATIVES | VERTELLUS HOLDINGS LLC (US) | 2022-04-28 | — | — | WO | claimed |
| CN-108623518-A | Amides compound containing trifluoromethyl pyridine and the preparation method and application thereof | 上海凯爱网络科技有限公司 | 2018-10-09 | — | — | CN | claimed |
| CN-102977009-B | A kind of synthetic method of 2-trifluoromethyl-3-fluorine pyridine | Ao Sainuo bio tech ltd, Hangzhou (CN) | 2015-07-29 | — | — | CN | claimed |
| EP-2041111-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2009-04-01 | — | — | EP | claimed |
| WO-2008002247-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | claimed |
| WO-1999041237-A1 | SUBSTITUTED PYRIDINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | G.D. SEARLE & CO. (US) | 1999-08-19 | — | — | WO | claimed |
| JP-3081263-A | — | — | None | — | — | JP | disclosed |
| CN-122071460-A | Amide compound with sterilization and insecticidal effects and application thereof | 帕潘纳(北京)科技有限公司 | 2026-05-22 | — | — | CN | disclosed |
| CN-122010831-A | Preparation method of 4-trifluoromethyl nicotinic acid | 衢州凯沃化工有限公司 | 2026-05-12 | — | — | CN | disclosed |
| US-20260055094-A1 | FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES INC (US) | 2026-02-26 | — | — | US | disclosed |
| US-12543674-B2 | Embryogenesis factors for cellular reprogramming of a plant cell | PIONEER HI-BRED INTERNATIONAL, INC. (US) | 2026-02-10 | — | — | US | disclosed |
| EP-0258201-A1 | 5-Sulfur substituted pyridine monocarboxylic herbicides | Monsanto Company (US) | 1988-03-02 | — | — | EP | disclosed |
| CN-87103510-A | Substituted pyridine herbicide | — | 1988-01-20 | — | — | CN | disclosed |
| US-4692184-A | HERBICIDES | MONSANTO COMPANY (US) | 1987-09-08 | — | — | US | disclosed |
| US-4655816-A | PLANT GROWTH REGULATORS | MONSANTO COMPANY (US) | 1987-04-07 | — | — | US | disclosed |
| EP-0181852-A1 | Substituted 2,6-substituted pyridine compounds | Monsanto Company (US) | 1986-05-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12543674-B2 | Embryogenesis factors for cellular reprogramming of a plant cell | CCNB2, CCNB1, CCNB3 | NAPRT 2278/4885KDM4E 3773/4885TDP1 3165/4885 |
| US-20260055094-A1 | FXR (NR1H4) MODULATING COMPOUNDS | NR1H4, NR1H2, NR1H3 | NAPRT 2751/4885KDM4E 3958/4885TDP1 4672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.