Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 7/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ADK | P55263 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31421618 | 0.84 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3DPP4 | |
| SCHEMBL12396830 | 0.83 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNB4CHRNA3LRRK2 | |
| SCHEMBL30665759 | 0.83 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNB4CHRNA3LRRK2 | |
| SCHEMBL7196139 | 0.83 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3DPP4 | |
| SCHEMBL7592708 | 0.83 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3DPP4 | |
| SCHEMBL12205229 | 0.82 | LRRK2 (0.51) | CHRNB2CHRNA4LRRK2KDM4ELMNA | |
| SCHEMBL20708231 | 0.81 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4725669 | 0.80 | KDM4E (0.51) | KDM4ENSD2LMNAMAPTTSHR | |
| SCHEMBL17843208 | 0.80 | CHRNB2 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3CHEK1 | |
| SCHEMBL14299569 | 0.80 | ADK (0.47) | CHRNB2CHRNA4CHEK1LRRK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143209-A | Biaryl amide compounds as kinase inhibitors | NOVARTIS AG | 2015-12-09 | — | — | CN | disclosed |