Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27993844 | 0.87 | POLB (0.50) | ALDH1A1SIGMAR1HRH3KDM4EMEN1 | |
| SCHEMBL27981787 | 0.86 | POLB (0.51) | LMNAALDH1A1HRH3HTTKDM4E | |
| SCHEMBL27524788 | 0.86 | SIGMAR1 (0.53) | LMNAALDH1A1SIGMAR1SMN1; SMN2KDM4E | |
| SCHEMBL28055968 | 0.84 | ALDH1A1 (0.41) | ALDH1A1SIGMAR1HTTKDM4EMEN1 | |
| SCHEMBL28277616 | 0.84 | ALDH1A1 (0.45) | ALDH1A1HRH3SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL27844699 | 0.83 | KDM4E (0.51) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL27844208 | 0.83 | KMT2A (0.43) | HRH3L3MBTL1MEN1KMT2AATM | |
| SCHEMBL27659430 | 0.83 | FAAH (0.40) | LMNAALDH1A1HRH3SMN1; SMN2HTT | |
| SCHEMBL28272975 | 0.83 | CHKA (0.56) | ALDH1A1SMN1; SMN2L3MBTL1HDAC6KDM4E | |
| SCHEMBL28279084 | 0.82 | ALDH1A1 (0.41) | ALDH1A1HRH3SMN1; SMN2HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837835-A | VEGFR3 inhibitors | CANCER THERAPEUTICS CRC PTY LTD | 2015-08-12 | — | — | CN | disclosed |
| CN-103626742-A | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC | 2014-03-12 | — | — | CN | disclosed |
| CN-101981036-B | Pyrrolo [2, 3-D] pyridines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG | 2013-09-04 | — | — | CN | disclosed |
| CN-101370792-B | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC | 2013-03-20 | — | — | CN | disclosed |
| CN-101506155-A | Biphenyl derivatives and their use in the treatment of hepatitis C | ARROW THERAPEUTICS LTD (GB) | 2009-08-12 | — | — | CN | disclosed |
| CN-101370792-A | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC (US) | 2009-02-18 | — | — | CN | disclosed |