Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | NEK2 | P51955 | 1/20 | 0.48 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6669387 | 0.82 | MAPT (0.56) | MAPTPRKD1CHEK1FGFR1NEK2 | |
| SCHEMBL17279957 | 0.81 | PRKD1 (0.67) | MAPTPRKD1CHEK1FGFR1NEK2 | |
| SCHEMBL25438397 | 0.77 | PRKD1 (0.69) | MAPTPRKD1TNIKSMN1; SMN2NPC1 | |
| SCHEMBL5020249 | 0.77 | MAPT (0.56) | MAPTCHEK1FGFR1NEK2MAPK15 | |
| SCHEMBL21247828 | 0.73 | TNIK (0.75) | TNIK | |
| SCHEMBL29965978 | 0.73 | TNIK (0.75) | TNIK | |
| SCHEMBL12364720 | 0.73 | RAB9A (0.55) | MAPTTNIKSMN1; SMN2NPC1RAB9A | |
| SCHEMBL15329674 | 0.73 | NQO2 (0.55) | MAPTCYP17A1CYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL6792137 | 0.72 | CYP17A1 (0.60) | MAPTCYP17A1CYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL28664306 | 0.71 | FYN (0.56) | MAPTPRKD1CHEK1FGFR1NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105061314-A | Neprilysin inhibitors | THERAVANCE INC | 2015-11-18 | — | — | CN | disclosed |
| CN-103261164-B | Enkephalinase inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-08-19 | — | — | CN | disclosed |