Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | NEK2 | P51955 | 1/20 | 0.54 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.53 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NQO2 | P16083 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17279957 | 0.84 | PRKD1 (0.67) | MAPTCHEK1FGFR1NEK2MAPK15 | |
| SCHEMBL28025353 | 0.82 | MAPT (0.52) | MAPTCHEK1FGFR1NEK2MAPK15 | |
| SCHEMBL22944984 | 0.81 | BRD4 (0.48) | CHEK1FGFR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25438397 | 0.81 | PRKD1 (0.69) | MAPTTNIKPRKD1NPC1RAB9A | |
| SCHEMBL5020249 | 0.77 | MAPT (0.56) | MAPTCHEK1FGFR1NEK2MAPK15 | |
| SCHEMBL21247828 | 0.76 | TNIK (0.75) | TNIK | |
| SCHEMBL29965978 | 0.76 | TNIK (0.75) | TNIK | |
| SCHEMBL11228972 | 0.76 | HSD17B10 (0.57) | MAPTCHEK1FGFR1NEK2MAPK15 | |
| SCHEMBL28664306 | 0.74 | FYN (0.56) | MAPTCHEK1FGFR1NEK2MAPK15 | |
| SCHEMBL5271443 | 0.74 | CHEK1 (0.57) | MAPTCHEK1FGFR1NEK2MAPK15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004028450-A2 | PROCESS OF MAKING PHENYLPYRAZOLES USEFUL AS SELECTIVE 5HT2A MODULATORS AND INTERMEDIATES THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-08 | — | — | WO | disclosed |