Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | GAK | O14976 | 3/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.33 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.33 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4381004 | 0.79 | SMN1; SMN2 (0.41) | HTTHSD17B10DYRK1AGAKRIPK2 | |
| SCHEMBL23148039 | 0.78 | DYRK1A (0.39) | HTTHSD17B10DYRK1AHASPINDYRK2 | |
| SCHEMBL4380382 | 0.78 | DYRK1A (0.39) | HTTHSD17B10DYRK1ANOS3NOS2 | |
| SCHEMBL29813440 | 0.78 | DYRK1A (0.39) | HTTHSD17B10DYRK1AHASPINDYRK2 | |
| SCHEMBL8417801 | 0.76 | AURKA (0.44) | DYRK1ANOS3NOS2NOS1DYRK2 | |
| SCHEMBL29954197 | 0.75 | DYRK1A (0.38) | HTTHSD17B10DYRK1AHASPINDYRK2 | |
| SCHEMBL30050747 | 0.75 | HTT (0.47) | HTTHSD17B10DYRK1ANOS3NOS2 | |
| SCHEMBL29023076 | 0.75 | HTT (0.47) | HTTHSD17B10DYRK1ANOS3NOS2 | |
| SCHEMBL31602251 | 0.74 | NOS2 (0.42) | DYRK1ANOS3NOS2NOS1AURKA | |
| SCHEMBL157196 | 0.74 | HTT (0.50) | HTTHSD17B10DYRK1ANOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104755465-A | Heterocyclic compounds | TAKEDA PHARMACEUTICAL | 2015-07-01 | — | — | CN | disclosed |