Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4369263 | 0.92 | GAA (0.50) | GAANR3C1SIGMAR1ELANEMEN1 | |
| SCHEMBL14498561 | 0.86 | GAA (0.43) | GAANR3C1SIGMAR1ELANEMEN1 | |
| SCHEMBL6582036 | 0.80 | NR3C1 (0.47) | GAANR3C1SIGMAR1CYP3A4MEN1 | |
| SCHEMBL4562285 | 0.80 | NR3C1 (0.44) | GAANR3C1SIGMAR1MEN1KMT2A | |
| SCHEMBL4364213 | 0.79 | GAA (0.53) | GAANR3C1SIGMAR1ELANEMEN1 | |
| SCHEMBL653269 | 0.77 | GAA (0.57) | GAANR3C1SIGMAR1ELANEMEN1 | |
| SCHEMBL6583420 | 0.75 | NR3C1 (0.44) | GAANR3C1SIGMAR1CYP3A4MEN1 | |
| SCHEMBL3315042 | 0.74 | NR3C1 (0.49) | GAANR3C1SIGMAR1CYP3A4HSD17B10 | |
| SCHEMBL13090069 | 0.74 | NR3C1 (0.52) | GAANR3C1SIGMAR1CYP3A4HSD17B10 | |
| Methane SCHEMBL726862 | 0.72 | NR3C1 (0.48) | GAANR3C1SIGMAR1CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104812748-B | Pyrazoline GPR40 conditioning agents | 百时美施贵宝公司 | 2017-10-24 | — | — | CN | disclosed |
| CN-104918935-B | dihydropyrazole GPR40 modulators | 百时美施贵宝公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-104812748-A | Dihydropyrazole GPR40 modulators | BRISTOL MYERS SQUIBB CO | 2015-07-29 | — | — | CN | disclosed |