Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13958468 | 0.85 | TP53 (0.56) | S1PR1NOTUMCCNA2CDK2CCNA1 | |
| SCHEMBL8352076 | 0.85 | CSF1R (0.47) | CCNA2CDK2CCNA1NPY2RPIM1 | |
| SCHEMBL14824602 | 0.82 | CHRM1 (0.50) | CCNA2CDK2CCNA1MAPTSMN1; SMN2 | |
| SCHEMBL13713426 | 0.81 | S1PR1 (0.46) | S1PR1NOTUMTAAR1NPY2R | |
| SCHEMBL26989913 | 0.79 | ALDH1A1 (0.50) | MAPTSMN1; SMN2 | |
| SCHEMBL13419179 | 0.79 | NOTUM (0.50) | S1PR1NOTUMTP53MAPT | |
| SCHEMBL3426862 | 0.79 | S1PR1 (0.51) | S1PR1NOTUMTAAR1NPY2RTP53 | |
| SCHEMBL14504001 | 0.77 | S1PR1 (0.45) | S1PR1NOTUMTAAR1NPY2RPIM1 | |
| SCHEMBL14536551 | 0.77 | LRRK2 (0.43) | S1PR1SMN1; SMN2 | |
| SCHEMBL28021938 | 0.77 | EML4 (0.48) | CCNA2CDK2CCNA1PIM1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104870446-B | Substituted pyrimidinyl and pyridinyl-pyrrolopyridinones, process for their preparation and their use as kinase inhibitors | 内尔维阿诺医学科学有限公司 | 2019-08-13 | — | — | CN | disclosed |
| CN-108047219-A | Substituted pyrimidine radicals and Pyridylpyrrole and pyridinone, its preparation method and its purposes as kinase inhibitor | 内尔维阿诺医学科学有限公司 | 2018-05-18 | — | — | CN | disclosed |
| CN-104870446-A | Substituted pyrimidinyl and pyridinyl-pyrrolopyridinones, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL | 2015-08-26 | — | — | CN | disclosed |