Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 14/20 | 0.74 |
| ▸ | MEN1 | O00255 | 12/20 | 0.74 |
| ▸ | POLB | P06746 | 10/20 | 0.74 |
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28028264 | 1.00 | KMT2A (0.74) | KMT2AMEN1POLBMAPTLMNA | |
| SCHEMBL28028736 | 0.90 | KMT2A (0.70) | KMT2AMEN1POLBMAPTLMNA | |
| SCHEMBL28028734 | 0.90 | KMT2A (0.70) | KMT2AMEN1POLBMAPTLMNA | |
| SCHEMBL28028261 | 0.75 | MMP13 (0.59) | KMT2AMEN1POLBMAPTKDM4E | |
| SCHEMBL28028262 | 0.75 | MMP13 (0.59) | KMT2AMEN1POLBMAPTKDM4E | |
| SCHEMBL12388106 | 0.73 | LMNA (0.73) | KMT2AMEN1POLBMAPTLMNA | |
| SCHEMBL12387900 | 0.71 | KDM4E (0.70) | KMT2AMEN1POLBMAPTLMNA | |
| SCHEMBL28136568 | 0.71 | POLB (0.79) | KMT2AMEN1POLBATMMGAM | |
| SCHEMBL28136571 | 0.71 | POLB (0.79) | KMT2AMEN1POLBATMMGAM | |
| SCHEMBL12387981 | 0.70 | LMNA (0.68) | KMT2AMEN1POLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104860866-B | 5- (substitution carbon acylamino) -1H- indoles -2- carbohydrazide derivatives and its preparation method and application | 厦门大学 | 2018-07-17 | — | — | CN | disclosed |
| CN-104860866-A | 5-(substituted carbonylamino)-1H-indole-2-carbohydrazide derivatives as well as preparation method and application thereof | UNIV XIAMEN | 2015-08-26 | — | — | CN | disclosed |