Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Piracetam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.86 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA3 | P07451 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piracetam SCHEMBL6140872 | 0.93 | TSHR (1.00) | TSHRPIK3CDLMNACA12CA1 | |
| Piracetam SCHEMBL20172 | 0.93 | TSHR (1.00) | TSHRPIK3CDLMNACA12CA1 | |
| Piracetam SCHEMBL28423013 | 0.91 | TSHR (0.96) | TSHRPIK3CDLMNACA12CA1 | |
| SCHEMBL24263535 | 0.87 | TSHR (0.89) | TSHRPIK3CDLMNAHTTKMT2A | |
| SCHEMBL1532937 | 0.85 | TSHR (0.85) | TSHRPIK3CDHTTKMT2ASMN1; SMN2 | |
| SCHEMBL8552055 | 0.81 | — | — | |
| Piracetam SCHEMBL27400400 | 0.80 | TSHR (0.69) | TSHRPIK3CDLMNACA12CA1 | |
| Alcohol SCHEMBL5284370 | 0.79 | PIK3CD (0.53) | TSHRPIK3CDLMNACA12CA1 | |
| SCHEMBL16984610 | 0.78 | TSHR (0.61) | TSHRPIK3CDLMNACA12CA1 | |
| Acetamide SCHEMBL1694656 | 0.78 | TSHR (0.61) | TSHRPIK3CDLMNACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104814955-B | A kind of pharmaceutical composition and its preparation for treating encephaledema | 山东罗欣药业集团股份有限公司 | 2018-01-12 | — | — | CN | disclosed |
| CN-104814955-A | Pharmaceutical composition for treating encephaledema | SHANDONG LUOXIN PHARMACEUTICAL GROUP CO LTD | 2015-08-05 | — | — | CN | disclosed |