Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | PPID | Q08752 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ENO1 | P06733 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28114744 | 0.80 | OPRM1 (0.42) | TACR1OPRM1LMNACYP2D6SLC6A2 | |
| SCHEMBL4522027 | 0.71 | SYK (0.46) | ATMKMT2ACYP2D6SLC6A2SLC6A4 | |
| SCHEMBL27783464 | 0.71 | PRKCA (0.38) | SMN1; SMN2 | |
| SCHEMBL27748184 | 0.70 | TACR1 (0.52) | TACR1OPRM1SLC6A4 | |
| SCHEMBL1224694 | 0.69 | TACR1 (0.41) | TACR1KMT2AGAACYP2D6SLC6A2 | |
| SCHEMBL1224690 | 0.69 | TACR1 (0.41) | TACR1KMT2AGAACYP2D6SLC6A2 | |
| SCHEMBL27598326 | 0.68 | CHRNA7 (0.37) | KMT2A | |
| SCHEMBL28000343 | 0.67 | SMN1; SMN2 (0.33) | SMN1; SMN2OPRM1 | |
| SCHEMBL28106576 | 0.67 | PRKCA (0.36) | — | |
| SCHEMBL6643951 | 0.67 | SLC6A2 (0.42) | CYP2D6SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105348266-A | Substituted-3-chlorin-N-[3-(pyrimidine-2-ylamine)phenyl]propanamide or salts thereof | ASTRAZENECA AB | 2016-02-24 | — | — | CN | disclosed |
| CN-105254616-A | 2-(2,4,5-SUBSTITUTED-ANILINO)PYRIMIDINE COMPOUNDS and salts thereof | ASTRAZENECA AB | 2016-01-20 | — | — | CN | disclosed |
| CN-105198862-A | 2 - (2, 4, 5 - SUBSTITUTED -ANILINO) PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANCER | ASTRAZENECA AB | 2015-12-30 | — | — | CN | disclosed |
| CN-105175396-A | Substituted 4-methoxy-N3-(pyrimidin-2-yl) benzene-1, 3-diamine compounds and salts thereof | ASTRAZENECA AB | 2015-12-23 | — | — | CN | disclosed |
| CN-103702990-B | 2- (2,4, 5-substituted aniline) pyrimidine derivatives as EGFR modulators for the treatment of cancer | ASTRAZENECA AB (SE) | 2015-09-09 | — | — | CN | disclosed |