Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 15/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 14/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 9/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 7/20 | 0.40 |
| ▸ | PSMB2 | P49721 | 6/20 | 0.40 |
| ▸ | PSMB10 | P40306 | 5/20 | 0.39 |
| ▸ | PSMB11 | A5LHX3 | 4/20 | 0.39 |
| ▸ | PSMA7 | O14818 | 4/20 | 0.39 |
| ▸ | PSMA1 | P25786 | 4/20 | 0.39 |
| ▸ | PSMA2 | P25787 | 4/20 | 0.39 |
| ▸ | PSMA3 | P25788 | 4/20 | 0.39 |
| ▸ | PSMA4 | P25789 | 4/20 | 0.39 |
| ▸ | PSMA5 | P28066 | 4/20 | 0.39 |
| ▸ | PSMB4 | P28070 | 4/20 | 0.39 |
| ▸ | PSMB6 | P28072 | 4/20 | 0.39 |
| ▸ | PSMB3 | P49720 | 4/20 | 0.39 |
| ▸ | PSMA6 | P60900 | 4/20 | 0.39 |
| ▸ | PSMA8 | Q8TAA3 | 4/20 | 0.39 |
| ▸ | PSMB7 | Q99436 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27502333 | 0.82 | SCN9A (0.57) | SCN9A | |
| SCHEMBL28336154 | 0.78 | SCN9A (0.56) | SCN9A | |
| SCHEMBL27438213 | 0.76 | SCN9A (0.54) | SCN9A | |
| SCHEMBL28628480 | 0.76 | SCN9A (0.54) | SCN9A | |
| SCHEMBL28529040 | 0.76 | SCN9A (0.53) | SCN9A | |
| SCHEMBL15568779 | 0.74 | CTSS (0.58) | PSMB8PSMB5PSMB9PSMB1PSMB2 | |
| SCHEMBL15568780 | 0.74 | CTSS (0.58) | PSMB8PSMB5PSMB9PSMB1PSMB2 | |
| SCHEMBL15568778 | 0.74 | CTSS (0.58) | PSMB8PSMB5PSMB9PSMB1PSMB2 | |
| SCHEMBL15594256 | 0.74 | CTSS (0.58) | PSMB8PSMB5PSMB9PSMB1PSMB2 | |
| SCHEMBL28029609 | 0.73 | SCN9A (0.56) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104797591-A | Fluorinated epoxyketone compounds and their use as proteasome inhibitors | SLASSI ABDELMALIK | 2015-07-22 | — | — | CN | disclosed |