Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30471275 | 0.91 | RIPK1 (0.61) | RIPK1MMP8HDAC3HDAC4HDAC1 | |
| SCHEMBL4765237 | 0.91 | RIPK1 (0.61) | RIPK1MMP8HDAC3HDAC4HDAC1 | |
| Alcohol SCHEMBL8617609 | 0.85 | RIPK1 (0.63) | RIPK1MMP8HDAC3HDAC4HDAC1 | |
| SCHEMBL28864860 | 0.83 | SRC (0.48) | ALDH1A1LMNA | |
| SCHEMBL28707389 | 0.79 | RIPK1 (0.59) | RIPK1MMP8HDAC3HDAC4HDAC1 | |
| SCHEMBL24263394 | 0.77 | RIPK1 (0.57) | RIPK1MMP8HDAC3HDAC4HDAC1 | |
| SCHEMBL7767276 | 0.77 | MEN1 (0.63) | KMT2AALDH1A1MAPTTSHRGAA | |
| SCHEMBL17792642 | 0.77 | RIPK1 (0.57) | RIPK1MMP8HDAC3HDAC4HDAC1 | |
| SCHEMBL28286652 | 0.77 | KMT2A (0.58) | HDAC1HDAC6KMT2AALDH1A1MAPT | |
| SCHEMBL181282 | 0.77 | RIPK1 (0.61) | RIPK1MMP8HDAC6KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104918928-A | Tricyclic compounds, their preparation and use | ZAFGEN INC | 2015-09-16 | — | — | CN | disclosed |
| CN-104918615-A | Methods of treating liver diseases | ZAFGEN INC | 2015-09-16 | — | — | CN | disclosed |