SCHEMBL181282

SCHEMBL181282

O=C(NCc1ccccc1)C(Cl)(Cl)Cl

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 1/20 0.61
MMP8 P22894 3/20 0.56
GAA P10253 1/20 0.53
KMT2A Q03164 2/20 0.52
CYP2D6 P10635 2/20 0.52
CYP2C19 P33261 2/20 0.52
MEN1 O00255 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2C9 P11712 1/20 0.52
TSHR P16473 1/20 0.52
SMN1; SMN2 Q16637 2/20 0.51
OPRK1 P41145 1/20 0.51
ALDH1A1 P00352 3/20 0.50
LMNA P02545 2/20 0.50
EPHX1 P07099 1/20 0.50
HPGD P15428 1/20 0.50
ALOX12 P18054 1/20 0.50
RAB9A P51151 1/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC8 Q9BY41 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8874156 0.84 BCHE (0.58) GAAKMT2AMEN1SMN1; SMN2ALDH1A1
SCHEMBL29592808 0.83 ALDH1A1 (0.49) RIPK1MMP8SMN1; SMN2OPRK1ALDH1A1
SCHEMBL10990271 0.82 RIPK1 (0.68) RIPK1MMP8GAAKMT2ACYP2C19
SCHEMBL624536 0.81 CYP2C9 (0.65) RIPK1KMT2ACYP2C19MEN1CYP2C9
SCHEMBL625014 0.81 TPSAB1 (0.61) KMT2ACYP2D6CYP2C19MEN1CYP1A2
SCHEMBL4963071 0.81 LMNA (0.56) KMT2ACYP2C19CYP1A2SMN1; SMN2ALDH1A1
SCHEMBL3116602 0.81 RIPK1 (0.57) RIPK1MMP8GAAKMT2ACYP2D6
SCHEMBL30471275 0.80 RIPK1 (0.61) RIPK1MMP8GAAKMT2ACYP2D6
SCHEMBL1516186 0.80 RIPK1 (0.71) RIPK1MMP8GAAKMT2ACYP2D6
SCHEMBL4765237 0.80 RIPK1 (0.61) RIPK1MMP8GAAKMT2ACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 160 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113880799-A Intermediate compound for preparing paclitaxel, synthesis method thereof and synthesis method of paclitaxel 南方科技大学 2022-01-04 CN claimed
CN-107899539-A There is magnetic montmorillonite being modified based on sodium of adsorption function and preparation method thereof to caesium 北京源清益壤环保科技有限公司 2018-04-13 CN claimed
CN-105623007-A High-temperature-resistant and ageing-resistant cable sheath material and preparing method thereof SUZHOU KEMAO ELECTRONIC MAT TECH CO LTD 2016-06-01 CN claimed
EP-2106403-A2 FUNCTIONALIZED BETA 1,6 GLUCOSAMINE DISACCHARIDES AND PROCESS FOR THEIR PREPARATION OM Pharma (CH) 2009-10-07 EP claimed
WO-2008059035-A2 FUNCTIONALIZED BETA 1,6 GLUCOSAMINE DISACCHARIDES AND PROCESS FOR THEIR PREPARATION OM PHARMA (CH) 2008-05-22 WO claimed
WO-2008059307-A2 FUNCTIONALIZED BETA 1,6 GLUCOSAMINE DISACCHARIDES AND PROCESS FOR THEIR PREPARATION OM PHARMA (CH) 2008-05-22 WO claimed
EP-1315559-B1 APPARATUS AND METHODS FOR THE AUTOMATED SYNTHESIS OF OLIGOSACCHARIDES MASSACHUSETTS INST TECHNOLOGY (US) 2006-03-22 EP claimed
EP-0660835-A4 PROCESS FOR PREPARING CERTAIN PYRROLO 3,4- -I(B))QUINOLINES, CERTAIN 1H-PYRANO 3',4':6,7)INDOLIZINO 1,2--I(B))QUINOLIN-3,14(4H,12H)-DIONES, AND CERTAIN 8-METHYL-7-(OXOPROPYL)-INDOLIZINO 1,2--I(B))QUINOLIN-9(11H)-ONES. 1995-08-16 EP claimed
EP-0660835-A1 PROCESS FOR PREPARING CERTAIN PYRROLO 3,4- $i(b)]QUINOLINES, CERTAIN 1H-PYRANO 3',4':6,7]INDOLIZINO 1,2-$i(b)]QUINOLIN-3,14(4H,12H)-DIONES, AND CERTAIN 8-METHYL-7-(OXOPROPYL)-INDOLIZINO 1,2-$i(b)]QUINOLIN-9(11H)-ONES SMITHKLINE BEECHAM CORPORATION (US) 1995-07-05 EP claimed
EP-3735975-B1 ERTUGLIFLOZIN FOR USE IN TREATING HEART FAILURE IN PATIENTS WITH DIABETES MERCK SHARP & DOHME LLC (US) 2025-12-03 EP disclosed
CN-118652195-A Process for producing chloro acetonitrile 江苏中科嘉骥智能制造有限公司 2024-09-17 CN disclosed
US-12036203-B2 Methods of treating or reducing the risk of cardiovascular events and related diseases using SGLT-2 inhibitors MERCK SHARP & DOHME LLC (US) 2024-07-16 US disclosed
CN-118265691-A Cyclohexylbeta-hydroxyalkylamines and their medical use 阿托基公司 2024-06-28 CN disclosed
EP-4232438-A1 COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE The Governors of the University of Alberta (CA) 2023-08-30 EP disclosed
WO-1994009010-A1 O-ALKYLATED RAPAMYCIN DERIVATIVES AND THEIR USE, PARTICULARLY AS IMMUNOSUPPRESSANTS SANDOZ LTD. (CH) 1994-04-28 WO disclosed
WO-1994002134-A1 CHOLESTEROL-LOWERING AGENTS MERCK & CO., INC. (US) 1994-02-03 WO disclosed
US-5264605-A Myoinsitol derivatives, process for preparing same, phosphorylating agent, and its utilization MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1993-11-23 US disclosed
EP-0505868-A2 N-Acyl-alpha-aminoacids derivatives F. HOFFMANN-LA ROCHE AG (CH) 1992-09-30 EP disclosed
EP-0443449-A2 Process for the preparation of oxetanones F. HOFFMANN-LA ROCHE AG (CH) 1991-08-28 EP disclosed
EP-0431197-A1 MYOINOSITOL DERIVATIVE AND METHOD OF PRODUCTION THEREOF, AND PHOSPHORYLATING AGENT AND ITS USE MITSUI TOATSU CHEMICALS, Inc. (JP) 1991-06-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12036203-B2 Methods of treating or reducing the risk of cardiovascular events and related diseases using SGLT-2 inhibitors SLC5A1, SLC5A2, GLP1R RIPK1 1511/4885MMP8 1199/4885GAA 524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.