Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 3/20 | 0.40 |
| ▸ | CCND1 | P24385 | 3/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL28704700 | 0.77 | KDM4E (0.50) | POLBRAD52SMN1; SMN2KDM4EGAA | |
| SCHEMBL27999716 | 0.73 | POLB (0.50) | POLBRAD52SMN1; SMN2KDM4EGAA | |
| SCHEMBL14115003 | 0.72 | TLR7 (0.57) | POLBRAD52SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL22016467 | 0.71 | POLB (0.37) | POLBRAD52SMN1; SMN2KDM4EGAA | |
| SCHEMBL21940322 | 0.71 | GAA (0.54) | POLBRAD52SMN1; SMN2KDM4EGAA | |
| SCHEMBL16132377 | 0.71 | GPR3 (0.47) | POLBSMN1; SMN2KDM4EGAAALDH1A1 | |
| SCHEMBL12533981 | 0.70 | KMT2A (0.64) | POLBRAD52SMN1; SMN2KDM4EGAA | |
| SCHEMBL21574734 | 0.70 | VKORC1 (0.50) | POLBRAD52SMN1; SMN2 | |
| SCHEMBL28093128 | 0.70 | RORC (0.47) | L3MBTL1MAPT | |
| SCHEMBL3343183 | 0.69 | KDM4E (0.69) | POLBRAD52SMN1; SMN2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104884448-A | Heteroaryl linked quinolinyl modulators of roryt | JANSSEN PHARMACEUTICA NV | 2015-09-02 | — | — | CN | disclosed |