Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | AXL | P30530 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28031380 | 0.88 | AXL (0.50) | MAPTHTTAXLMEN1PSIP1 | |
| SCHEMBL3191937 | 0.84 | TLR9 (0.57) | MAPTHTTMEN1LMNAALDH1A1 | |
| SCHEMBL27887749 | 0.82 | CYP2A6 (0.47) | MAPTHTTMEN1LMNAPOLB | |
| SCHEMBL27483583 | 0.79 | CYP2A6 (0.56) | MAPTHTTMEN1LMNAPOLB | |
| SCHEMBL14906702 | 0.77 | CYP2A6 (0.67) | MAPTHTTAXLMEN1PSIP1 | |
| SCHEMBL14474112 | 0.75 | GBA1 (0.41) | MAPTHTTMEN1LMNAALDH1A1 | |
| SCHEMBL7601945 | 0.75 | EGFR (0.45) | MAPTHTTMEN1LMNAPOLB | |
| SCHEMBL15617051 | 0.75 | CYP2A6 (0.69) | MAPTHTTAXLMEN1PSIP1 | |
| SCHEMBL24335889 | 0.74 | PIK3CA (0.55) | MAPTHTTAXLMEN1PSIP1 | |
| SCHEMBL2239546 | 0.73 | NPC1 (0.50) | MAPTHTTMEN1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105218516-A | Therapeutic compounds and related methods of use | OTSUKA PHARMA CO LTD | 2016-01-06 | — | — | CN | disclosed |
| CN-102883723-B | Therapeutic compounds and related methods of use | OTSUKA PHARMACEUTICAL CO.,LTD. (JP) | 2015-09-16 | — | — | CN | disclosed |