Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28031300 | 0.88 | MAPT (0.52) | AXLMEN1PSIP1MKNK1MKNK2 | |
| SCHEMBL26674871 | 0.83 | EGFR (0.50) | MEN1HTTMAPTLMNAEGFR | |
| SCHEMBL27483583 | 0.79 | CYP2A6 (0.56) | MEN1HTTMAPTLMNAPOLB | |
| SCHEMBL29529239 | 0.78 | BACE1 (0.46) | MEN1HTTLMNAEGFRALDH1A1 | |
| SCHEMBL26674921 | 0.78 | BACE1 (0.46) | MEN1HTTLMNAEGFRALDH1A1 | |
| SCHEMBL26674961 | 0.77 | HTR3A (0.49) | MEN1HTTMAPTLMNAEGFR | |
| SCHEMBL15617051 | 0.75 | CYP2A6 (0.69) | AXLMEN1PSIP1MKNK1MKNK2 | |
| SCHEMBL26674905 | 0.74 | L3MBTL1 (0.51) | MEN1HTTMAPTLMNAPOLB | |
| SCHEMBL29529153 | 0.73 | NPC1 (0.50) | MEN1HTTMAPTLMNAPOLB | |
| SCHEMBL27887749 | 0.73 | CYP2A6 (0.47) | MEN1HTTMAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105218516-A | Therapeutic compounds and related methods of use | OTSUKA PHARMA CO LTD | 2016-01-06 | — | — | CN | disclosed |
| CN-102883723-B | Therapeutic compounds and related methods of use | OTSUKA PHARMACEUTICAL CO.,LTD. (JP) | 2015-09-16 | — | — | CN | disclosed |