Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.61 |
| ▸ | EGFR | P00533 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | AXL | P30530 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14906625 | 0.83 | TLR9 (0.58) | CYP2A6PDGFRBPDGFRAEGFRMAPT | |
| SCHEMBL14906701 | 0.82 | PDGFRB (0.62) | CYP2A6PDGFRBPDGFRAEGFRMAPT | |
| SCHEMBL13304740 | 0.80 | CYP11B2 (0.71) | CYP2A6MAPTHTTAXLMEN1 | |
| SCHEMBL3612716 | 0.80 | CYP2A6 (1.00) | CYP2A6PDGFRBPDGFRAEGFRMAPT | |
| SCHEMBL29746239 | 0.80 | CYP2A6 (1.00) | CYP2A6PDGFRBPDGFRAEGFRMAPT | |
| SCHEMBL29832072 | 0.78 | CYP2A6 (0.93) | CYP2A6PDGFRBPDGFRAEGFRMAPT | |
| SCHEMBL28031300 | 0.77 | MAPT (0.52) | CYP2A6EGFRMAPTHTTAXL | |
| SCHEMBL31060290 | 0.76 | PDGFRB (1.00) | CYP2A6PDGFRBPDGFRAEGFRMAPT | |
| SCHEMBL14906805 | 0.76 | RAB9A (0.62) | CYP2A6PDGFRBPDGFRAEGFRALDH1A1 | |
| SCHEMBL30604173 | 0.73 | NPC1 (0.75) | CYP2A6PDGFRBPDGFRAEGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10039759-B2 | Quinolines as FGFR kinase modulators | ASTEX THERAPEUTICS LTD (GB) | 2018-08-07 | — | — | US | disclosed |
| US-10039759-B2 | Quinolines as FGFR kinase modulators | ASTEX THERAPEUTICS LTD (GB) | 2018-08-07 | — | — | US | disclosed |
| EP-2776397-B1 | QUINOLINES AS FGFR KINASE MODULATORS | ASTEX THERAPEUTICS LTD (GB) | 2017-11-29 | — | — | EP | disclosed |
| US-9439896-B2 | Quinolines as FGFR kinase modulators | ASTEX THERAPEUTICS LTD (GB) | 2016-09-13 | — | — | US | disclosed |
| US-9439896-B2 | Quinolines as FGFR kinase modulators | ASTEX THERAPEUTICS LTD (GB) | 2016-09-13 | — | — | US | disclosed |
| US-20140296236-A1 | QUINOLINES AS FGFR KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2014-10-02 | — | — | US | disclosed |
| US-20140296236-A1 | QUINOLINES AS FGFR KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2014-10-02 | — | — | US | disclosed |
| WO-2013061074-A1 | QUINOLINES AS FGFR KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10039759-B2 | Quinolines as FGFR kinase modulators | FGFR1, FGFR3, FGFR2 | CYP2A6 1702/4885PDGFRB 38/4885PDGFRA 45/4885 |
| US-20140296236-A1 | QUINOLINES AS FGFR KINASE MODULATORS | FGFR1, FGFR2, FGFR3 | CYP2A6 1840/4885PDGFRB 36/4885PDGFRA 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.