SCHEMBL28031707

SCHEMBL28031707

COC(=O)c1c(-c2ccc(OC)cc2)cn(-c2ccccc2)c1C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
L3MBTL1 Q9Y468 4/20 0.46
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
GFER P55789 1/20 0.46
PTPN11 Q06124 2/20 0.46
GABRA2 P47869 2/20 0.45
GABRA1 P14867 1/20 0.45
GABRG2 P18507 1/20 0.45
GABRB3 P28472 1/20 0.45
GABRA5 P31644 1/20 0.45
GABRA3 P34903 1/20 0.45
GABRB2 P47870 1/20 0.44
ABL1 P00519 1/20 0.42
EGFR P00533 1/20 0.42
SRC P12931 1/20 0.42
KDR P35968 1/20 0.42
ABL2 P42684 1/20 0.42
RAB9A P51151 2/20 0.42
KDM4E B2RXH2 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28031631 0.95 PTPN11 (0.47) ALDH1A1L3MBTL1MEN1KMT2AGFER
SCHEMBL28078513 0.92 MEN1 (0.49) ALDH1A1MEN1KMT2AGABRA1GABRG2
SCHEMBL28031651 0.89 KMT2A (0.48) ALDH1A1L3MBTL1MEN1KMT2AGABRA2
SCHEMBL28031775 0.89 TP53 (0.45) ALDH1A1MEN1KMT2AGFERPTPN11
SCHEMBL28032238 0.88 SLC6A4 (0.47) ALDH1A1MEN1KMT2AGABRA2GABRA1
SCHEMBL28031629 0.87 KDM4E (0.47) ALDH1A1L3MBTL1MEN1KMT2AGFER
SCHEMBL28032226 0.85 GFER (0.44) ALDH1A1L3MBTL1MEN1KMT2AGFER
SCHEMBL28032234 0.85 MEN1 (0.45) ALDH1A1L3MBTL1MEN1KMT2APTPN11
SCHEMBL28032225 0.84 AR (0.46) ALDH1A1MEN1KMT2APTPN11RAB9A
SCHEMBL28031624 0.84 GAA (0.46) ALDH1A1MEN1KMT2APTPN11GABRA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105017126-B Perfluoroalkyl azole derivatives and its synthetic method 上海麦克林生化科技有限公司 2018-01-19 CN disclosed
CN-105646322-A Perfluoroalkyl pyrrole derivative and synthesis method thereof 上海大学 2016-06-08 CN disclosed
CN-105017126-A Perfluoroalkyl pyrrole derivative and synthesis method thereof UNIV SHANGHAI 2015-11-04 CN disclosed