SCHEMBL28032234

SCHEMBL28032234

COC(=O)c1c(-c2ccccc2)cn(-c2ccc(C)cc2)c1C(F)(F)F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.45
KMT2A Q03164 4/20 0.45
ABCB1 P08183 1/20 0.44
HTT P42858 2/20 0.43
GABRA1 P14867 2/20 0.41
GABRG2 P18507 2/20 0.41
GABRB3 P28472 2/20 0.41
GABRA3 P34903 2/20 0.41
GABRA5 P31644 1/20 0.41
LMNA P02545 3/20 0.40
MAPT P10636 3/20 0.40
ALDH1A1 P00352 5/20 0.40
HPGD P15428 3/20 0.40
PRKCZ Q05513 1/20 0.40
TSHR P16473 1/20 0.39
MAPK1 P28482 1/20 0.39
HSD17B10 Q99714 1/20 0.39
TUBB4A P04350 1/20 0.39
TUBB P07437 1/20 0.39
TUBA3C P0DPH7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28031651 0.95 KMT2A (0.48) MEN1KMT2AABCB1HTTGABRA1
SCHEMBL28078513 0.93 MEN1 (0.49) MEN1KMT2AHTTGABRA1GABRG2
SCHEMBL28031643 0.92 MEN1 (0.44) MEN1KMT2AABCB1HTTGABRA1
SCHEMBL28194102 0.90 MEN1 (0.43) MEN1KMT2AABCB1HTTGABRA1
SCHEMBL28031624 0.89 GAA (0.46) MEN1KMT2AHTTGABRA1GABRG2
SCHEMBL28031631 0.89 PTPN11 (0.47) MEN1KMT2AGABRA1GABRG2GABRB3
SCHEMBL28032232 0.89 HTT (0.42) MEN1KMT2AHTTGABRA1GABRG2
SCHEMBL28031622 0.87 KMT2A (0.43) MEN1KMT2AHTTGABRA1GABRG2
SCHEMBL28032227 0.85 HTT (0.41) MEN1KMT2AHTTGABRA1GABRG2
SCHEMBL28031707 0.85 ALDH1A1 (0.46) MEN1KMT2AHTTGABRA1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105017126-B Perfluoroalkyl azole derivatives and its synthetic method 上海麦克林生化科技有限公司 2018-01-19 CN disclosed
CN-105646322-A Perfluoroalkyl pyrrole derivative and synthesis method thereof 上海大学 2016-06-08 CN disclosed
CN-105017126-A Perfluoroalkyl pyrrole derivative and synthesis method thereof UNIV SHANGHAI 2015-11-04 CN disclosed