Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | CDC25B | P30305 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15924131 | 0.80 | TRIM24 (0.34) | TRIM24TRIM33PDE10AALDH1A1LMNA | |
| SCHEMBL3878940 | 0.76 | PDE10A (0.43) | TRIM24TRIM33PDE10AALDH1A1LMNA | |
| SCHEMBL19083206 | 0.76 | TRIM24 (0.34) | TRIM24TRIM33ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28020728 | 0.76 | ERN1 (0.43) | TRIM24TRIM33ALDH1A1LMNANPC1 | |
| SCHEMBL25552636 | 0.73 | CHRNB4 (0.42) | ALDH1A1NPC1RAB9A | |
| SCHEMBL3684308 | 0.73 | PDE10A (0.43) | PDE10AALDH1A1GRM4LMNASMN1; SMN2 | |
| SCHEMBL30181916 | 0.72 | — | — | |
| SCHEMBL610170 | 0.72 | — | — | |
| Formaldehyde SCHEMBL29210889 | 0.72 | APLNR (0.43) | PDE10AALDH1A1DRD1NPC1RAB9A | |
| SCHEMBL29133119 | 0.72 | HTR2A (0.40) | TRIM24TRIM33ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102781942-B | Octahydro pyrrolo-[3,4-c] pyrroles is replaced as two of orexin receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2015-09-23 | — | — | CN | disclosed |