Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27642568 | 0.88 | POLB (0.50) | LMNAPOLBALDH1A1HPGDBCL2L1 | |
| SCHEMBL28032643 | 0.84 | MEN1 (0.55) | PIK3CAPI4KBPIK3CDPIK3CBPI4KA | |
| SCHEMBL28032642 | 0.82 | PDK2 (0.45) | LMNAPOLBPIK3CAPI4KBMAP4K4 | |
| SCHEMBL18356741 | 0.79 | HSD17B1 (0.60) | PIK3CAPI4KBPIK3CDPIK3CBPI4KA | |
| SCHEMBL15674492 | 0.79 | NT5E (0.49) | HPGDPIK3CAPI4KBMAP4K4KCNH2 | |
| SCHEMBL16404616 | 0.78 | TRPV4 (0.52) | PIK3CAPI4KBMAP4K4KCNH2MINK1 | |
| SCHEMBL23263925 | 0.77 | PIK3CA (0.43) | PIK3CAPI4KBMAP4K4KCNH2MINK1 | |
| SCHEMBL15674535 | 0.74 | KCNH2 (0.47) | ALDH1A1HSD17B10PIK3CAPI4KBMAP4K4 | |
| SCHEMBL16068085 | 0.74 | GRIN1 (0.55) | ALDH1A1PIK3CAPI4KBPIK3CDPIK3CB | |
| SCHEMBL322603 | 0.73 | KIF11 (0.52) | PIK3CAPI4KBMAP4K4KCNH2MINK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104854090-A | Heteroaryl derivatives and uses thereof | JACOBUS PHARMACEUTICAL COMPANY INC | 2015-08-19 | — | — | CN | disclosed |