Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.53 |
| ▸ | PARP1 | P09874 | 7/20 | 0.53 |
| ▸ | F7 | P08709 | 1/20 | 0.53 |
| ▸ | F3 | P13726 | 1/20 | 0.53 |
| ▸ | TDP2 | O95551 | 2/20 | 0.52 |
| ▸ | PARP11 | Q9NR21 | 4/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | F11 | P03951 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20894239 | 0.94 | PARP10 (0.58) | PARP10PARP1F7F3TDP2 | |
| SCHEMBL29631237 | 0.94 | PARP10 (0.58) | PARP10PARP1F7F3TDP2 | |
| SCHEMBL30337030 | 0.81 | PARP11 (0.58) | PARP10PARP1TDP2PARP11PDPK1 | |
| SCHEMBL1417726 | 0.81 | PARP11 (0.58) | PARP10PARP1TDP2PARP11PDPK1 | |
| SCHEMBL30420500 | 0.80 | PARP10 (0.57) | PARP10PARP1F7F3TDP2 | |
| SCHEMBL14395011 | 0.80 | PARP10 (0.61) | PARP10PARP1F7F3TDP2 | |
| SCHEMBL5879567 | 0.78 | TDP2 (0.61) | TDP2SRD5A1SRD5A2F11KDM4E | |
| SCHEMBL19150148 | 0.77 | SRD5A2 (0.53) | PARP10PARP1TDP2PARP11PDPK1 | |
| SCHEMBL12663981 | 0.77 | PARP10 (0.56) | PARP10PARP1F7F3TDP2 | |
| SCHEMBL14395236 | 0.77 | PARP10 (0.56) | PARP10PARP1F7F3PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104870435-A | Aryl and heteroaryl fused lactams | PFIZER | 2015-08-26 | — | — | CN | disclosed |