Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL608613 | 0.81 | ALDH1A1 (0.61) | ALDH1A1TDP1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL212215 | 0.81 | ALDH1A1 (0.51) | ALDH1A1TDP1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL4217288 | 0.79 | ALDH1A1 (0.52) | ALDH1A1TDP1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL735278 | 0.78 | ALDH1A1 (0.59) | ALDH1A1TDP1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL18269389 | 0.78 | HCAR2 (0.46) | ALDH1A1TDP1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL10930919 | 0.78 | ALDH1A1 (0.47) | ALDH1A1TDP1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL16672852 | 0.75 | ALDH1A1 (0.51) | ALDH1A1TDP1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL17724583 | 0.75 | ALDH1A1 (0.51) | ALDH1A1TDP1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL5555255 | 0.75 | CA12 (0.44) | ALDH1A1TDP1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL5133280 | 0.75 | CA12 (0.44) | ALDH1A1TDP1MAPK1L3MBTL1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772159-B2 | Solution and solid phase synthesis of pyrrolinones and polypyrrolinones | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-08-10 | — | — | US | disclosed |
| US-6891046-B2 | Solution and solid phase synthesis of pyrrolinones and polypyrrolinones | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE | 2005-05-10 | — | — | US | disclosed |
| US-20050004371-A1 | Solution and solid phase synthesis of pyrrolinones and polypyrrolinones | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2005-01-06 | — | — | US | disclosed |
| US-20020133027-A1 | New solution and solid phase synthesis of pyrrolinones and polypyrrolinones | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE | 2002-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004371-A1 | Solution and solid phase synthesis of pyrrolinones and polypyrrolinones | VARS1, QPCT, AAAS | ALDH1A1 2454/4885TDP1 2097/4885MAPK1 3027/4885 |
| US-20020133027-A1 | New solution and solid phase synthesis of pyrrolinones and polypyrrolinones | VARS1, PPOX, QPCT | ALDH1A1 2496/4885TDP1 1760/4885MAPK1 2836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.