VARS1

Valine--tRNA ligase · P26640 · VARS1 on Sugi Atlas →

0 patent compounds predicted against VARS1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to VARS1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Personalized Antisense Oligonucleotide for A Single Participant With GARS1 Gene Mutation Associated With Charcot-Marie-Tooth Disease Type 2D (CMT2D) PHASE1/PHASE2ENROLLING_BY_INVITATION
Evaluate the Tolerability and Therapeutic Effects of Repeated Doses of Autologous T Cells With VRX496 in HIV PHASE1COMPLETED
Clinical Genetics Branch Eligibility Screening Survey nanNOT_YET_RECRUITING
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
PREcision Diagnostics in Rare genetIC Diseases and Tumors - Long Read Sequencing nanRECRUITING
Genetic Variants in Linear Localized Scleroderma nanCOMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance nanCOMPLETED
Quantifying Disease Progression in LBSL nanUNKNOWN
Multicenter Analysis of Genomic and Metabolic Data of Neonatal Genetic Diseases nanUNKNOWN
Characteristics of Idiopathic Familial Voice Disorders nanCOMPLETED
Prospective Study to Assess Medical Performance of Optical Mapping and Long Read Sequencing in Detecting Numerical and Structural Chromosome Abnormalities nanCOMPLETED
Genetic Analysis of Fraser Syndrome and Fryns Syndrome nanCOMPLETED
New Strategies of Genetic Study of Patients With Oculocutaneous Albinism nanCOMPLETED
Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors nanCOMPLETED
Vascular Liver Disease Evaluation, Follow Up and Non-Invasive Diagnostics Program nanRECRUITING
Better Delineation of DDX3X Related Phenotype and Epigenetic Signature. nanUNKNOWN
Identification and Characterization of Novel Non-Coding Variants That Contribute to Genetic Disorders nanCOMPLETED
Vocal Pattern Assessment as a New Key to Identifying Rare Syndromes nanUNKNOWN
Clinical and Genetic Studies of VACTERL Association nanCOMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts nanCOMPLETED
COsegregation of VARiants in Panel of Genes nanRECRUITING
Delineating the Molecular Spectrum and the Clinical, Imaging and Neuronal Phenotype of Chopra-Amiel-Gordon Syndrome nanRECRUITING
Genetic Basis of Mitral Valve Prolapse nanUNKNOWN
Zoektocht Naar Erfelijke MetaBole Aandoening (Dutch)/ Solve The Unsolved (English) nanCOMPLETED
The Value of circRNAs (hsa_circ_0004001) in Early Diagnosis of HCC nanUNKNOWN
Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis nanCOMPLETED
Genetic Investigation of Cancer Predisposition nanNOT_YET_RECRUITING
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients nanRECRUITING
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature. nanUNKNOWN
Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles nanACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a VARS1 binder may also engage these)

ProteinNameSimilarity
Q04462 1.000 Q04462 →
Q9Z1Q9 0.999 Q9Z1Q9 →
Q15031 0.995 Q15031 →
Q2T9L8 0.991 Q2T9L8 →
P49696 0.990 P49696 →
Q6MG21 0.989 Q6MG21 →
MARS2 Methionine--tRNA ligase, mitochondrial 0.988 landscape →
Q767M3 0.988 Q767M3 →
Q8BYM8 0.987 Q8BYM8 →
Q5ST30 0.986 Q5ST30 →
Q4R646 0.986 Q4R646 →
A6H7E1 0.986 A6H7E1 →
P28350 0.985 P28350 →
IARS2 Isoleucine--tRNA ligase, mitochondrial 0.985 landscape →
Q9Y7Y8 0.985 Q9Y7Y8 →
Q9HA77 0.985 Q9HA77 →
Q68FL6 0.984 Q68FL6 →
Q8BIJ6 0.984 Q8BIJ6 →
Q3U2A8 0.983 Q3U2A8 →
Q5RCH4 0.983 Q5RCH4 →
Q8VDC0 0.982 Q8VDC0 →
Q7V9I9 0.982 Q7V9I9 →
Q499X9 0.982 Q499X9 →
P13503 0.981 P13503 →
Q9JX22 0.981 Q9JX22 →
MARS1 Methionine--tRNA ligase, cytoplasmic 0.981 landscape →
Q2QMG2 0.981 Q2QMG2 →
Q7NS57 0.981 Q7NS57 →
Q5JPH6 0.980 Q5JPH6 →
Q6PF21 0.980 Q6PF21 →