Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylalanine SCHEMBL7006272 | 0.90 | OPRK1 (0.39) | KMT2AGHSRALPIPKMPTGS1 | |
| Phenylalanine SCHEMBL1836984 | 0.89 | OPRK1 (0.39) | KMT2AGHSRALPIPKMPTGS1 | |
| Phenylalanine SCHEMBL3099767 | 0.88 | ALPI (0.48) | GHSRALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL21878868 | 0.88 | ALPI (0.48) | GHSRALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL1675279 | 0.88 | ALPI (0.48) | GHSRALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL28033410 | 0.87 | ALPI (0.43) | GHSRALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL15901818 | 0.87 | SLC7A5 (0.49) | KMT2AALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL29067183 | 0.86 | GHSR (0.39) | GHSRALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL28078389 | 0.86 | KMT2A (0.36) | KMT2AGHSRALPIPKMPTGS1 | |
| Phenylalanine SCHEMBL6255424 | 0.85 | GHSR (0.37) | GHSRALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470523-B2 | Method for detecting intracellular interaction between biomolecules | CIS BIO INTERNATIONAL (FR) | 2013-06-25 | — | — | US | disclosed |
| US-20090215106-A1 | METHOD FOR DETECTING INTRACELLULAR INTERACTION BETWEEN BIOMOLECULES | CIS BIO INTERNATIONAL (FR) | 2009-08-27 | — | — | US | disclosed |
| EP-1929294-A2 | METHOD FOR DETECTING INTRACELLULAR INTERACTION BETWEEN BIOMOLECULES | CIS BIO INTERNATIONAL (FR) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007028921-A2 | METHOD FOR DETECTING INTRACELLULAR INTERACTION BETWEEN BIOMOLECULES | CIS BIO INTERNATIONAL (FR) | 2007-03-15 | — | — | WO | disclosed |