Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 2/20 | 0.72 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.72 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Minodronic Acid SCHEMBL145238 | 0.84 | FDPS (1.00) | FDPSGGPS1GPR84EPHB3NPC1 | |
| Minodronic Acid SCHEMBL6009958 | 0.83 | FDPS (0.97) | FDPSGGPS1GPR84EPHB3NPC1 | |
| Minodronic Acid SCHEMBL8661646 | 0.83 | FDPS (0.97) | FDPSGGPS1GPR84EPHB3NPC1 | |
| SCHEMBL12309035 | 0.80 | FDPS (0.73) | FDPSGGPS1GPR84EPHB3NPC1 | |
| (2-Hydroxy-3-Imidazo[1,2-A]Pyridin-3-Yl-2-Phosphonopropionic Acid (Enantionmers) SCHEMBL7858749 | 0.80 | FDPS (0.72) | FDPSGGPS1GPR84EPHB3NPC1 | |
| SCHEMBL17519343 | 0.80 | FDPS (0.72) | FDPSGGPS1GPR84EPHB3NPC1 | |
| Minodronic Acid SCHEMBL8661643 | 0.80 | FDPS (0.85) | FDPSGGPS1GPR84EPHB3NPC1 | |
| Minodronic Acid SCHEMBL8659642 | 0.79 | FDPS (0.83) | FDPSGGPS1GPR84EPHB3NPC1 | |
| Minodronic Acid SCHEMBL8664061 | 0.79 | FDPS (0.83) | FDPSGGPS1GPR84EPHB3NPC1 | |
| SCHEMBL17519328 | 0.78 | GGPS1 (0.69) | FDPSGGPS1GPR84EPHB3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115282269-A | Combination therapy involving anti-claudin 18.2 antibodies for the treatment of cancer | 安斯泰来制药株式会社 | 2022-11-04 | — | — | CN | disclosed |
| CN-115177733-A | Combination therapy involving anti-claudin 18.2 antibodies for the treatment of cancer | 安斯泰来制药株式会社 | 2022-10-14 | — | — | CN | disclosed |
| CN-105073777-B | Combination therapy involving anti-claudin 18.2 antibodies for the treatment of cancer | 安斯泰来制药株式会社 | 2022-07-01 | — | — | CN | disclosed |
| CN-105189554-B | Therapy involving antibodies against claudin 18.2 for the treatment of cancer | 安斯泰来制药株式会社 | 2021-10-08 | — | — | CN | disclosed |
| CN-105189554-A | Therapy involving antibodies against claudin 18.2 for treatment of cancer | GANYMED PHARMACEUTICALS AG | 2015-12-23 | — | — | CN | disclosed |
| CN-105073777-A | Combination therapy involving anti-claudin 18.2 antibodies for the treatment of cancer | GANYMED PHARMACEUTICALS AG | 2015-11-18 | — | — | CN | disclosed |