Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 3/20 | 0.72 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.72 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Minodronic Acid SCHEMBL145238 | 0.84 | FDPS (1.00) | FDPSGGPS1GPR84NPC1RAB9A | |
| Minodronic Acid SCHEMBL6009958 | 0.83 | FDPS (0.97) | FDPSGGPS1GPR84NPC1RAB9A | |
| Minodronic Acid SCHEMBL8661646 | 0.83 | FDPS (0.97) | FDPSGGPS1GPR84NPC1RAB9A | |
| SCHEMBL23272074 | 0.81 | FDPS (0.49) | FDPSGGPS1LMNA | |
| SCHEMBL12309035 | 0.80 | FDPS (0.73) | FDPSGGPS1GPR84NPC1RAB9A | |
| Minodronic Acid SCHEMBL8661643 | 0.80 | FDPS (0.85) | FDPSGGPS1GPR84NPC1RAB9A | |
| SCHEMBL17519343 | 0.80 | FDPS (0.72) | FDPSGGPS1GPR84NPC1RAB9A | |
| SCHEMBL28033480 | 0.80 | FDPS (0.72) | FDPSGGPS1GPR84NPC1RAB9A | |
| Minodronic Acid SCHEMBL8664061 | 0.79 | FDPS (0.83) | FDPSGGPS1GPR84NPC1RAB9A | |
| Minodronic Acid SCHEMBL8659642 | 0.79 | FDPS (0.83) | FDPSGGPS1GPR84NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11400104-B2 | Skeletal removal of bisphosphonates | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-08-02 | — | — | US | claimed |
| CN-109219438-B | Bone removal of bisphosphonates | 加州大学董事会 | 2022-04-22 | — | — | CN | claimed |
| US-20210121485-A1 | Skeletal Removal of Bisphosphonates | UNIV CALIFORNIA (US) | 2021-04-29 | — | — | US | claimed |
| US-10857165-B2 | Skeletal removal of bisphosphonates | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-12-08 | — | — | US | disclosed |
| US-20190209590-A1 | Skeletal Removal of Bisphosphonates | UNIVERSITY OF SOUTHERN CALIFORNIA | 2019-07-11 | — | — | US | disclosed |
| EP-3463380-A1 | SKELETAL REMOVAL OF BISPHOSPHONATES | The Regents of The University of California (US) | 2019-04-10 | — | — | EP | disclosed |
| US-20180064829-A1 | FLUORESCENT BISPHOSPHONATE ANALOGS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2018-03-08 | — | — | US | disclosed |
| EP-3278107-A1 | FLUORESCENT BISPHOSPHONATE ANALOGS | University of Southern California (US) | 2018-02-07 | — | — | EP | disclosed |
| WO-2017210272-A1 | SKELETAL REMOVAL OF BISPHOSPHONATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-12-07 | — | — | WO | disclosed |
| WO-2016161407-A1 | FLUORESCENT BISPHOSPHONATE ANALOGS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2016-10-06 | — | — | WO | disclosed |
| EP-0788362-B1 | PHOSPONOCARBOXYLATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | PROCTER & GAMBLE PHARMA (US) | 2001-07-25 | — | — | EP | disclosed |
| CN-1048017-C | Phosphonocarboxylate compounds and pharmaceutical compositions containing the same | PROCTER & GAMBLE PHARMA (US) | 2000-01-05 | — | — | CN | disclosed |
| CN-1230409-A | Phosphonocarboxylate compounds and pharmaceutical compositions containing the same | PROCTER & GAMBLE PHARMA (US) | 1999-10-06 | — | — | CN | disclosed |
| CN-1224018-A | Phosphonic carboxylate compounds, pharmaceutical compositions contg. same | PROCTER & GAMBLE PHARMA (US) | 1999-07-28 | — | — | CN | disclosed |
| US-5760021-A | TREATING OR PREVENTING METABOLIC BONE DISORDERS | THE PROCTER & GAMBLE COMPANY (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0788362-A1 | PHOSPONOCARBOXYLATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1997-08-13 | — | — | EP | disclosed |
| CN-1089613-A | Phosphonocarboxylate compounds and pharmaceutical compositions containing the same | PROCTER & GAMBLE PHARMA (US) | 1994-07-20 | — | — | CN | disclosed |
| WO-1993024131-A1 | PHOSPONOCARBOXYLATE COMPOUNDS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1993-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210121485-A1 | Skeletal Removal of Bisphosphonates | SOST, ACP3, PTH1R | FDPS 1272/4885GGPS1 271/4885GPR84 3461/4885 |
| US-20180064829-A1 | FLUORESCENT BISPHOSPHONATE ANALOGS | PPIP5K2, PHPT1, PTH1R | FDPS 362/4885GGPS1 215/4885GPR84 3637/4885 |
| US-20190209590-A1 | Skeletal Removal of Bisphosphonates | SOST, ACP3, PTH1R | FDPS 1272/4885GGPS1 271/4885GPR84 3461/4885 |
| US-11400104-B2 | Skeletal removal of bisphosphonates | SOST, ACP3, PTH1R | FDPS 1272/4885GGPS1 271/4885GPR84 3461/4885 |
| US-10857165-B2 | Skeletal removal of bisphosphonates | SOST, ACP3, PTH1R | FDPS 1272/4885GGPS1 271/4885GPR84 3461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.