Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Minodronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 9/20 | 0.97 |
| ▸ | GGPS1 | O95749 | 3/20 | 0.97 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Minodronic Acid SCHEMBL145238 | 0.99 | FDPS (1.00) | FDPSGGPS1GPR84BTN3A1PDE3A | |
| Minodronic Acid SCHEMBL6009958 | 0.97 | FDPS (0.97) | FDPSGGPS1GPR84BTN3A1PDE3A | |
| Minodronic Acid SCHEMBL8661643 | 0.91 | FDPS (0.85) | FDPSGGPS1GPR84BTN3A1PDE3A | |
| Minodronic Acid SCHEMBL8664061 | 0.90 | FDPS (0.83) | FDPSGGPS1GPR84BTN3A1PDE3A | |
| Minodronic Acid SCHEMBL8659642 | 0.90 | FDPS (0.83) | FDPSGGPS1GPR84BTN3A1PDE3A | |
| SCHEMBL12309035 | 0.83 | FDPS (0.73) | FDPSGGPS1GPR84NPSR1DRD4 | |
| (2-Hydroxy-3-Imidazo[1,2-A]Pyridin-3-Yl-2-Phosphonopropionic Acid (Enantionmers) SCHEMBL7858749 | 0.83 | FDPS (0.72) | FDPSGGPS1GPR84NPSR1DRD4 | |
| SCHEMBL17519343 | 0.83 | FDPS (0.72) | FDPSGGPS1GPR84NPSR1DRD4 | |
| SCHEMBL28033480 | 0.83 | FDPS (0.72) | FDPSGGPS1GPR84NPSR1DRD4 | |
| SCHEMBL17519328 | 0.81 | GGPS1 (0.69) | FDPSGGPS1GPR84NPSR1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647649-B1 | NOVEL CRYSTAL OF MONOHYDRATE OF HETEROCYCLIC BIS(PHOSPHONIC ACID) DERIVATIVE | YAMANOUCHI PHARMA CO LTD (JP) | 1998-11-11 | — | — | EP | disclosed |
| US-5480875-A | 1-HYDROXY-2-(IMIDAZO(1,2A)PYRIDIN-3-YL)ETHANE-1,1-BIS (PHOSPHONIC ACID) | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0647649-A1 | NOVEL CRYSTAL OF MONOHYDRATE OF HETEROCYCLIC BIS(PHOSPHONIC ACID) DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1995-04-12 | — | — | EP | disclosed |