Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 4/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1422745 | 0.85 | HTT (0.42) | RENHTTTP53MAPTPOLB | |
| SCHEMBL1423127 | 0.84 | REN (0.40) | RENHTTTP53POLBSMN1; SMN2 | |
| SCHEMBL1423244 | 0.84 | REN (0.40) | RENHTTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL2218461 | 0.84 | MAPT (0.47) | RENHTTMAPTKDM4EALDH1A1 | |
| SCHEMBL2219018 | 0.83 | HTT (0.52) | RENHTTTP53MAPTPOLB | |
| SCHEMBL2219776 | 0.80 | REN (0.37) | RENHTTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL28034366 | 0.80 | PPARG (0.40) | RENHTTTP53MAPTPOLB | |
| SCHEMBL28034294 | 0.79 | PPARG (0.42) | RENHTTTP53MAPTPOLB | |
| SCHEMBL1422586 | 0.77 | ALDH1A1 (0.39) | RENHTTSMN1; SMN2LMNAPPARG | |
| SCHEMBL3456050 | 0.76 | KCNN4 (0.42) | HTTTP53SMN1; SMN2ALOX12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103373985-B | Heterocyclic compounds and their use | TAKEDA PHARMACEUTICAL CO.,LTD. (JP) | 2015-10-28 | — | — | CN | disclosed |