Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL920141 | 0.80 | TDP1 (0.60) | EPHX2TDP1MAPK1RARBGAA | |
| SCHEMBL1244396 | 0.78 | TDP1 (0.48) | EPHX2TDP1MAPK1RARBGAA | |
| SCHEMBL27949226 | 0.78 | — | — | |
| SCHEMBL28034975 | 0.76 | EPHX2 (0.34) | EPHX2TDP1MAPK1TSHR | |
| SCHEMBL28034976 | 0.76 | TDP1 (0.33) | EPHX2TDP1MAPK1 | |
| SCHEMBL10608344 | 0.75 | RARB (0.50) | EPHX2TDP1MAPK1RARBGAA | |
| SCHEMBL1462725 | 0.75 | TDP1 (0.42) | EPHX2TDP1MAPK1TP53SMN1; SMN2 | |
| SCHEMBL658916 | 0.75 | FDPS (0.47) | EPHX2TDP1MAPK1RARBGAA | |
| SCHEMBL8960107 | 0.74 | TDP1 (0.41) | EPHX2TDP1MAPK1GAAHTT | |
| SCHEMBL8960105 | 0.74 | TDP1 (0.41) | EPHX2TDP1MAPK1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105153146-A | Novel 3-hydroxyisothiazole 1-oxide derivative | MOCHIDA PHARM CO LTD | 2015-12-16 | — | — | CN | disclosed |
| CN-103517898-B | Novel 3-hydroxyisothiazole 1-oxide derivatives | MOCHIDA PHARMACEUTICAL CO.,LTD. (JP) | 2015-09-30 | — | — | CN | disclosed |