Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1244396 | 0.90 | TDP1 (0.48) | TDP1MAPK1EPHX2HTTGAA | |
| SCHEMBL10608344 | 0.86 | RARB (0.50) | TDP1MAPK1EPHX2GAAMAPT | |
| SCHEMBL658916 | 0.86 | FDPS (0.47) | TDP1MAPK1EPHX2HTTGAA | |
| 1,4-Diisopentoxybenzene SCHEMBL2846102 | 0.84 | TDP1 (0.79) | TDP1MAPK1EPHX2HTTGAA | |
| SCHEMBL1462725 | 0.82 | TDP1 (0.42) | TDP1MAPK1EPHX2SMN1; SMN2TP53 | |
| SCHEMBL8960105 | 0.81 | TDP1 (0.41) | TDP1MAPK1EPHX2HTTGAA | |
| SCHEMBL8960107 | 0.81 | TDP1 (0.41) | TDP1MAPK1EPHX2HTTGAA | |
| SCHEMBL28034969 | 0.80 | EPHX2 (0.41) | TDP1MAPK1EPHX2HTTGAA | |
| SCHEMBL10785918 | 0.79 | KCNA3 (0.43) | TDP1MAPK1GAAMAPTALDH1A1 | |
| SCHEMBL8941219 | 0.79 | TDP1 (0.41) | TDP1MAPK1EPHX2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 242 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106232120-B | Process for preparing N-benzyl-3-hydroxy-4-substituted-pyridin-2- (1H) -ones | 爱尔皮奥治疗有限公司 | 2021-01-08 | — | — | CN | claimed |
| US-9388135-B2 | Process for preparing N-benzyl-3-hydroxy-4-substituted-pyridin-2-(1H)-ones | AERPIO THERAPEUTICS, INC. (US) | 2016-07-12 | — | — | US | claimed |
| US-20150232425-A1 | PROCESS FOR PREPARING N-BENZYL-3-HYDROXY-4-SUBSTITUTED-PYRIDIN-2-(1H)-ONES | AERPIO THERAPEUTICS, INC. | 2015-08-20 | — | — | US | claimed |
| CN-101812058-A | Indometacin 2-arylmorpholine ethyl, preparation method and application thereof | UNIV HUNAN | 2010-08-25 | — | — | CN | claimed |
| CN-101812033-A | Ibuprofen 2-arylmorpholine ethyl ester as well as preparation method and application thereof | UNIV HUNAN | 2010-08-25 | — | — | CN | claimed |
| US-5338742-A | Nematicidal use of 4-aralkylpyridines | DOWELANCO (US) | 1994-08-16 | — | — | US | claimed |
| EP-0556377-A4 | NEMATICIDAL USE OF 4-ARALKYLPYRIDINES | DOWELANCO (US) | 1994-05-18 | — | — | EP | claimed |
| EP-0556377-A1 | NEMATICIDAL USE OF 4-ARALKYLPYRIDINES | DOWELANCO (US) | 1993-08-25 | — | — | EP | claimed |
| WO-1993004579-A1 | NEMATICIDAL USE OF 4-ARALKYLPYRIDINES | DOWELANCO (US) | 1993-03-18 | — | — | WO | claimed |
| US-20240216389-A1 | DRUG FOR PREVENTING AND/OR TREATING POLYCYSTIC KIDNEY DISEASE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2024-07-04 | — | — | US | disclosed |
| CN-114423742-B | Benzotriazole-based compound, light absorber and resin composition | 三井化学株式会社 | 2024-05-28 | — | — | CN | disclosed |
| US-11957691-B2 | Drug for preventing and/or treating polycystic kidney disease | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2024-04-16 | — | — | US | disclosed |
| CN-117466830-A | Benzotriazole-based compound, light absorber and resin composition | 三井化学株式会社 | 2024-01-30 | — | — | CN | disclosed |
| WO-2024005030-A1 | DIPHENYLETHENE-BASED COMPOUND, LIGHT ABSORBER, RESIN COMPOSITION, AND USE THEREOF | 山本化成株式会社 | 2024-01-04 | — | — | WO | disclosed |
| US-4256891-A | (2-Amino-2-oxoethoxy)acetic acid compounds | MCNEIL LABORATORIES, INC. (US) | 1981-03-17 | — | — | US | disclosed |
| US-4203991-A | (Piperidino oxoethoxy)acetic acid compounds, compositions and methods | MCNEILAB, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4197315-A | (2-Amino-2-oxoethoxy)acetic acid compounds, compositions and methods | MCNEIL LABORATORIES, INC. (US) | 1980-04-08 | — | — | US | disclosed |
| US-4123538-A | (2-Amino-2-oxoethoxy)acetic acid compounds, compositions and methods | MCNEIL LABORATORIES, INCORPORATED (US) | 1978-10-31 | — | — | US | disclosed |
| US-RE29577-E | Anthraquinone dyestuffs | BAYER AKTIENGESELLSCHAFT (DT) | 1978-03-14 | — | — | US | disclosed |
| US-3963763-A | Anthraquinone dyestuffs | BAYER AKTIENGESELLSCHAFT (DT) | 1976-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232425-A1 | PROCESS FOR PREPARING N-BENZYL-3-HYDROXY-4-SUBSTITUTED-PYRIDIN-2-(1H)-ONES | CYP4B1, CYP8B1, HPD | TDP1 3373/4885MAPK1 2056/4885EPHX2 334/4885 |
| US-11957691-B2 | Drug for preventing and/or treating polycystic kidney disease | PKD1, PKD2, SSTR5 | TDP1 3294/4885MAPK1 3706/4885EPHX2 2991/4885 |
| US-20240216389-A1 | DRUG FOR PREVENTING AND/OR TREATING POLYCYSTIC KIDNEY DISEASE | PKD1, PKD2, SSTR5 | TDP1 3294/4885MAPK1 3706/4885EPHX2 2991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.