Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3626478 | 0.89 | RAB9A (0.61) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| Hydrogen Sulfide SCHEMBL28276156 | 0.87 | RAB9A (0.59) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| Bicarbonate SCHEMBL7346713 | 0.82 | HPGD (0.51) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| Bicarbonate SCHEMBL7346726 | 0.81 | ALDH1A1 (0.50) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| Bicarbonate SCHEMBL7346716 | 0.81 | ALDH1A1 (0.50) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| Piperazine SCHEMBL27994121 | 0.79 | RAB9A (0.51) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL2097299 | 0.78 | KDM4E (0.49) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL28057892 | 0.77 | RAB9A (0.50) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL3478457 | 0.76 | SCN9A (0.49) | CA2CA9CA12CA1EDNRA | |
| Benzene SCHEMBL27668000 | 0.76 | LTA4H (0.45) | RAB9AALDH1A1SMN1; SMN2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330477-A | A kind of tolylthiophene sulfamide compound, pharmaceutical composition, preparation method and application | 中国科学院上海有机化学研究所 | 2019-10-15 | — | — | CN | claimed |
| CN-109384764-A | Tolylthiophene sulfamide compound, pharmaceutical composition, preparation method and application | 中国科学院上海有机化学研究所 | 2019-02-26 | — | — | CN | claimed |
| CN-103450149-B | Tolylthiophene sulfamide compound and its production and use | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2015-10-14 | — | — | CN | claimed |
| CN-110330477-A | A kind of tolylthiophene sulfamide compound, pharmaceutical composition, preparation method and application | 中国科学院上海有机化学研究所 | 2019-10-15 | — | — | CN | disclosed |
| CN-110330477-A | A kind of tolylthiophene sulfamide compound, pharmaceutical composition, preparation method and application | 中国科学院上海有机化学研究所 | 2019-10-15 | — | — | CN | disclosed |
| CN-110330477-A | A kind of tolylthiophene sulfamide compound, pharmaceutical composition, preparation method and application | 中国科学院上海有机化学研究所 | 2019-10-15 | — | — | CN | disclosed |
| CN-109384764-A | Tolylthiophene sulfamide compound, pharmaceutical composition, preparation method and application | 中国科学院上海有机化学研究所 | 2019-02-26 | — | — | CN | disclosed |
| CN-109384764-A | Tolylthiophene sulfamide compound, pharmaceutical composition, preparation method and application | 中国科学院上海有机化学研究所 | 2019-02-26 | — | — | CN | disclosed |
| CN-109384764-A | Tolylthiophene sulfamide compound, pharmaceutical composition, preparation method and application | 中国科学院上海有机化学研究所 | 2019-02-26 | — | — | CN | disclosed |
| CN-103450149-B | Tolylthiophene sulfamide compound and its production and use | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2015-10-14 | — | — | CN | disclosed |
| CN-103450149-B | Tolylthiophene sulfamide compound and its production and use | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2015-10-14 | — | — | CN | disclosed |
| CN-103450149-B | Tolylthiophene sulfamide compound and its production and use | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2015-10-14 | — | — | CN | disclosed |